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中文摘要：
糖基化是一种重要的蛋白质翻译后修饰过程，蛋白质的糖基化影响免疫分子的结构与功能，影响机体对抗原的应答反应，也与许多疾病密切相关。本项目拟在合成方法上取得突破，合成具有生物活性的特征糖肽，探讨糖基化对多肽结构及生物活性的影响；研究化学合成的糖肽，如O-糖基化或N-糖基化丙肝病毒（HCV）抗原表位诱导的特异性CTL免疫反应和体液免疫反应变化；探讨O-糖肽的合成对T细胞功能和免疫系统的影响；同时合成出相关的N-糖链和O-糖链的衍生物，筛选出一些有望用于疾病的诊断、治疗和预防的药物先导物。
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期刊论文
Characterization of Copper Binding to the Peptide Amyloid-?(1–16) Associated with Alzheimer’s Diseas
The self-assembly ability of the first microtubule-binding repeat from tau and its modulation by pho
Novel acetylation aided Migrating Rearrangement of Uridine-diphosphate-N-acetylglucosamine in Electr
O-GlcNAcylation modulates the self-aggregation ability of the
fourth microtubule-binding repeat of t
Alternative O-GlcNAcylation/O-Phosp-horylation of Ser16 Induce Different Conformational Disturbances
Engineering of N-glycosylation of Hepatitis C Virus Envelope Protein E2 Enhances T cell responses fo
An attenuated Salmonella-vectored vaccine elicits protective immunity against Mycobacterium tubercul
Facile synthesis of a pentasaccharide mimic of a fragment of the capsular polysaccharide of Streptoc
Specifically binding of L-ficolin to N-glycans of HCV envelope glycoproteins E1 and E2 leads to comp
Aptamer from whole-bacterium SELEX as new therapeutic reagent against virulent Mycobacterium tubercu
Facile synthesis of cyclopeptide-centered multivalent glycoclusters with “click chemistry” and molec
会议论文
Knockdown of Core 1b 1,3-galactosyltransferase in Mouse muscle tissues prolongs mouse skin allograft
CS-SELEX generates high-affinity ssDNA aptamers as molecular probes for Hepatitis C Virus envelope g
L-ficolin contributes host resistance against Salmonella infection and stimulates gamma interferon p
Effect of L-ficolin on host resistance, gamma interferon production and phagocytosis againgest Salmo
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