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中文摘要：
前期研究发现，与正常膀胱粘膜相比浸润性膀胱癌中Notch-1表达显著下降，miRNA基因芯片分析显示浸润性膀胱癌细胞T24和5637与人膀胱上皮永生化细胞株SV-HUC-1相比有5种靶向Notch-1的miRNA显著升高，其中过表达miR-34a后Notch-1及下游HES-1蛋白表达显著下调。本课题拟进一步通过miRNA基因芯片筛选，生物信息学分析，Real-time PCR, pMIR-REPORT荧光素酶报告系统，miRNA功能缺失及过表达，膀胱癌细胞皮下成瘤裸鼠动物模型等手段，研究浸润性膀胱癌中靶向Notch-1的miRNA的功能及分子机制；系统分析这些miRNA的差异表达与膀胱癌的临床分期、病理分级、患者预后等的关系,评价血清及尿液中miRNA作为标志物的价值。从miRNA入手阐明浸润性膀胱癌中Notch-1异常表达的具体机制可为膀胱癌的治疗提供新的靶点和理论依据。
结论摘要：
英文主题词Notch1；DLL1；bladder cancer；microRNA；renal cancer
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期刊论文
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