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中文摘要：
肿瘤坏死因子α诱导蛋白8样分子2（Tumor necrosis factor-α induced protein 8 like 2, TIPE2） 是新发现的一个重要免疫负调控分子，具有调节宿主免疫和适应性免疫的作用。我们前期研究表明慢性HBV感染存在免疫紊乱，TIPE2可能参与了CD4+辅助性T细胞的调控，但其机制未明。我们提出如下科学假设① TIPE2基因可以调节HBV感染Th细胞亚群的分化；②NF-kB通路可能是TIPE2调控Th细胞分化的有效信号转导途径。为论证上述科学问题，本研究从临床、细胞模型和动物模型三个方面，运用基因敲除小鼠、细胞转染、RNA干扰、信号转导和免疫学技术，研究TIPE2在HBV感染中对Th细胞分化功能的调节作用和分子机制，对深入揭示乙型肝炎的免疫机制、寻找新型免疫治疗靶点具有重要的理论意义和应用价值。
结论摘要：
英文主题词Tumor necrosis factor-α induced protein 8 like 2；Hepatitis B virus；Immune response；Epigenetic；Liver failure
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期刊论文
Increased A20 mRNA Level in Peripheral Blood Mononuclear Cells is Associated With Immune Phases of P
Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepa
Aberrant DNA methylation of G-protein-coupled bile acid receptor Gpbar1 predicts prognosis of acute-
Methylation of suppressor of cytokine signalling 1 gene promoter is associated with acute-on-chronic
Association between Ras association domain family 1A promoter methylation and hepatocellular carcino
Exportin 4 gene expression and DNA promoter methylation status in chronic hepatitis B virus infectio
Comparison of intramuscular compound betamethasone and oral diclofenac sodium in the treatment of ac
Methylation of the Glutathione-S-Transferase P1 Gene Promoter Is Associated with Oxidative Stress in
Up-regulation of A20 gene expression in peripheral blood mononuclear cells is associated with acute-
A model to predict antiviral treatment in HBeAg negative chronic hepatitis B with alanine aminotrans
TIPE2 mRNA Level in PBMCs Serves as a Novel Biomarker for Predicting Short-Term Mortality of Acute-o
Methylation of tissue factor pathway inhibitor 2 as a prognostic biomarker for hepatocellular carcin
Overexpression of serum sST2 is associated with poor prognosis in acute-on-chronic hepatitis B liver
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