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中文摘要：
瞄准国家战略需求和学科发展的国际前沿，选择海洋无脊椎动物分子免疫学这一热点领域开展工作，先后主持国家自然科学重点基金、973和863等多项科研项目。获得扇贝EST序列12000余条，克隆参与免疫识别、信号转导以及效应分子基因150多个，为深入研究扇贝免疫防御的分子机制奠定了基础；确定软体动物中存在Myd88依赖型Toll信号转导途径、补体类似物和相应的补体系统，发现扇贝中存在免疫致敏现象，与免疫识别和吞噬有关，丰富了无脊椎动物免疫学的内容；构建了扇贝的遗传连锁图谱，发现扇贝在抗病性状上存在杂交优势，从免疫因子基因中筛选出与抗病相关的功能性SNP，对良种创制有指导作用。近5年共发表论文83篇，其中SCI/EI收录57篇，被SCI源论文引用176次（他引115次），获授权发明专利3项。相关研究成果分获国家海洋局创新成果二等奖（排名第一）和山东省自然科学二等奖。
英文摘要：
Scallop；Immune recognition；Signal transduction；Immune regulation；Immune defence
结论摘要：
本课题以重要海水养殖双壳类扇贝为研究材料，克隆获得45个扇贝免疫相关基因，查明了这些基因的表达调控规律以其编码蛋白的免疫学功能，从而系统揭示了扇贝七大类模式识别受体的识别作用、TLR和TNF等四条免疫相关信号通路以及免疫效应因子的作用机制，并深入阐明了扇贝免疫系统的发生与母源免疫、儿茶酚胺等神经内分泌系统的免疫调节和抗病抗逆相关免疫基因SNP等重要免疫调控机制。扇贝模式识别方式、TLR信号转导通路、补体样系统和神经内分泌免疫调节网络等相关研究的突出进展使之处于国内外领先水平。这些研究成果系统勾勒出双壳贝类免疫应答特征及其基本过程，初步阐明了双壳贝类免疫防御的分子机制，极大地丰富了无脊椎动物的免疫学理论，也为脊椎动物固有免疫系统和适应性免疫系统的进化提供了重要线索。相关研究成果共发表SCI论文52篇，撰写英文专著1部，申请发明专利5项，获得省部级奖励2项，培养博士后、博士和硕士研究生21名（其中博士后2名，博士11名，硕士8名）。
成果综合统计
期刊论文
会议论文
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期刊论文
A Novel Cold-Regulated Cold Shock Domain Containing Protein from Scallop Chlamys farreri with Nuclei
Cflec-5, a pattern recognition receptor in scallop Chlamys farreri agglutinating yeast Pichia pastor
Molecular cloning and transcriptional regulation of an allograft inflammatory factor-1 (AIF-1) in Zh
A C1q Domain Containing Protein from Scallop Chlamys farreri Serving as Pattern Recognition Receptor
An iodothyronine deiodinase from Chlamys farreri and its induced mRNA expression after LPS stimulati
Alternation of immune parameters and cellular energy allocation of Chlamys farreri under ammonia-N e
Association of CfLGBP gene polymorphism with disease susceptibility/resistance of Zhikong scallop (C
The increased transcriptional response and translocation of a Rel/NF-kappa B homologue in scallop Ch
A four-CRD C-type lectin from Chlamys farreri mediating nonself-recognition with broader spectrum an
Genomic organization, polymorphisms and molecular evolution of the goose-type lysozyme gene from Zhi
Peptidoglycan recognition protein of Chlamys farreri (CfPGRP-S1) mediates immune defenses against ba
CfLGBP, a pattern recognition receptor in Chlamys farreri involved in the immune response against va
AiC1qDC-1, a novel gC1q-domain-containing protein from bay scallop Argopecten irradians with fungi a
The Gln32Lys Polymorphism in HSP22 of Zhikong Scallop Chlamys farreri Is Associated with Heat Tolera
Immune response and energy metabolism of Chlamys farreri under Vibrio anguillarum challenge and high
The polymorphism in the promoter region of metallothionein 1 is associated with heat tolerance of sc
Maternal transfer of immunity in scallop Chlamys farreri and its trans-generational immune protectio
A macrophage migration inhibitory factor like gene from scallop Chlamys farreri: Involvement in immu
The expression of immune-related genes during the ontogenesis of scallop Chlamys farreri and their r
Association between the polymorphism of CfPGRP-S gene and disease susceptibility/resistance of zhiko
A novel scavenger receptor-cysteine-rich (SRCR) domain containing scavenger receptor identified from
A multi-CRD C-type lectin with broad recognition spectrum and cellular adhesion from Argopecten irra
Scallop phenylalanine hydroxylase implicates in immune response and can be induced by human TNF-alph
A C-type lectin (AiCTL-3) from bay scallop Argopecten irradians with mannose/galactose binding abili
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