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中文摘要：
免疫识别是免疫应答的起始阶段，对"自己"和"异己"的有效识别是整个免疫防御的基础和关键。模式识别受体和病原体相关分子模式（PAMP）间的模式识别作用是免疫识别的核心和根本。本项目以栉孔扇贝和海湾扇贝为对象，采用分子生物学和分子免疫学的手段，克隆识别结合革兰氏阳性、阴性细菌、真菌及病毒或其对应PAMP（包括肽聚糖、脂多糖、葡聚糖、CpG 和dsRNA 等）的基因，分析确定免疫识别受体基因的基本结构特征及其序列多态性，从细胞和个体水平研究这些基因在PAMP或微生物刺激下的表达特征，明确扇贝中存在的免疫识别途径以及免疫识别作用对后续免疫应答反应的激活和诱导作用，探讨扇贝和病原之间的相互作用过程，深入了解扇贝天然免疫的机制，丰富和发展海水无脊椎动物免疫学的内容，亦为海水养殖无脊椎动物优良种质创制，免疫增强剂的筛选及相关机理研究提供理论基础。
结论摘要：
英文主题词Gene clone; expression; pattern recognition receptors
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期刊论文
First molluscan TNFR homologue in Zhikong scallop: Molecular characterization and expression analysi
Molecular cloning and characterization of peroxiredoxin 6 from Chinese mitten crab Eriocheir sinensi
cDNA cloning and mRNA expression of a selenium-dependent glutathione peroxidase from Zhikong scallop
A multi-CRD C-type lectin with broad recognition spectrum and cellular adhesion from Argopectenirrad
Molecular cloning and expression of a novel Kazal-type serine proteinase inhibitor gene from Zhikong
Molecular cloning, characterization and expression of heat shock protein 90 gene in the haemocytes o
A prophenoloxidase from the Chinese mitten crab Eriocheir sinensis: Gene cloning, expression and act
cDNA cloning, characterization and mRNA expression of a pacifastin light chain gene from the Chinese
The enhanced immune protection of Zhikong scallop Chlamys farreri on the secondary encounter with Li
A novel C1q-domain-containing protein from Zhikong scallop Chlamys farreri with lipopolysaccharide b
An interleukin-2 enhancer binding factor 2 homolog involved in immune response from Chinese mitten c
A putative endocrine factor SIBD (single insulin binding domain protein) involved in immune response
The responsive expression of heat shock protein 22 gene in zhikong scallop Chlamys farreri against a
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