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STUDY ON MECHANICAL INTERACTIONS BETWEEN SINGLE CARDIAC MYOCYTE AND ELASTIC SUBSTRATE
  • ISSN号:0894-9166
  • 期刊名称:《固体力学学报:英文版》
  • 时间:0
  • 分类:O343[理学—固体力学;理学—力学] Q463[生物学—生理学]
  • 作者机构:[1]Department of Biomedical Engineering, Peking University, Beijing 100871, China, [2]Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China, [3]Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100083, China
  • 相关基金:Project supported by the National Basic Research Program (Grant No.2007CB935602) and the National Natural Science Foundation of China (Grant Nos.90607004, 10672005 and 10872008).
中文摘要:

心脏的 myocytes 的机械特征上的量的调查有重要生理的意义。基于有弹性的底层技术,这份报纸为高效率的细胞的拖拉恢复开发一套算法。由适用,到磁道的一个基于坡度的数字图象关联方法随机在单个心脏的 myocyte 导致的使变形的底层上散布了 uorescence microbeads,高分辨率的底层排水量地能乐意地被获得。由基于不可分的 Boussinesq 答案使用一个数字算法,房间底层拖拉以一种稳定、可靠的方式被重建。最后,当它遵守 polyacrylamide 橡皮底层,单个心脏的 myocyte 的空间与时间的动力学被调查。

英文摘要:

Quantitative investigation on mechanical characteristics of cardiac myocytes has important physiological significance. Based on elastic substrate technique, this paper develops a set of algorithms for high-efficiency cellular traction recovery. By applying a gradient-based digital image correlation method to track randomly distributed fluorescence microbeads on the deformed substrate induced by single cardiac myocyte, high-resolution substrate displacement field can readily be obtained. By using a numerical algorithm based on the integral Boussinesq solution, cell-substrate tractions are reconstructed in a stable and reliable manner. Finally, spatiotemporal dynamics of a single cardiac myocyte is investigated as it adheres to a polyacrylamide elastic substrate.

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期刊信息
  • 《固体力学学报:英文版》
  • 主管单位:
  • 主办单位:中国力学学会
  • 主编:郑泉水
  • 地址:武汉市珞喻路1037号华中科技大学南一楼西北508室
  • 邮编:430074
  • 邮箱:amss@mail.hust.edu.cn
  • 电话:027-87543737
  • 国际标准刊号:ISSN:0894-9166
  • 国内统一刊号:ISSN:42-1121/O3
  • 邮发代号:
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:133