中文摘要：

Slug（Snail2）是一种具有锌指结构的上皮一间质转化（epithelial—mesenchymal transition，EMT）转录因子，在肿瘤EMT过程及癌细胞的迁移、侵袭、转移和干细胞样特性维持中起重要作用，多种信号分子及转导途径参与Slug的表达调控。本文综述了调节Slug降解和表达的信号分子及转导途径、Slug诱导的几种肿瘤相关分子及Slug与其EMT转录因子的关系。

英文摘要：

Slug is a transcriptional factor of epithelial-mesenchymal transition （EMT） with zinc finger structures, which plays a crucial role in the process of EMT, migration, invasion, metastasis, and sustain of stem cell-like characteristics of cancer cells. A variety of signal transduction molecules and pathways are involved in the regulation of the expression of Slug. This review focuses on the signal molecules and signal transduction pathways which are involved in the regulation of the degradation and expression of Slug, various tumor-associated molecules induced by Slug, and the relationship between Slug and other EMT transcriptional factors.