中文摘要：

上皮-间质转化（epithelial—to-mesenchymal transition，EMT）是肿瘤侵袭和转移的首要步骤。ZEB1是EMT的关键转录因子之一，在肺癌EMT发生中起重要作用。ZEB1受LKB1等抑癌基因突变、miRNAs（如miR-200、miR-34a）水平、炎症或低氧肿瘤微环境等肺癌细胞内外因素的影响，主要通过抑制E—cadherin表达，引起肺癌细胞表型间质化。此外，ZEB1诱导肺癌EMT可能与TGF-β、COX-2等信号转导途径有关。

英文摘要：

Epithelial-to-mesenchymal transition （EMT） is the initial step of tumor invasion and metastasis. ZEB 1, a crucial transcription factor of EMT, plays a crucial role in the EMT of lung cancer. ZEB1, affected by multiple endogenous and exogenous factors, such as anti-oncogene mutation, inflammatory and hypoxic tumor environment and miRNAs （miR-200, miR-34a） level, inhibits E-cadherin expression, leading to the induction of mesenchymal phenotype in lung cancer cells. Moreover, TGF-β and COX-2 signaling pathways may be involved in EMT of lung cancer induced by ZEB 1.