目的将调查非最优的健康地位的生物指示物并且提供对非最优的健康地位的客观评价的工具。我们为诊断 SHS 给了统一标准的方法。我们在我们从 2807 个题目随机选择了并且收集的 407 种情况中测试了各种各样的实验室指示物 fasting 的 15 mL 从每个案例的静脉的血。我们测量了浆液免疫球蛋白 A (IgA ) 和免疫球蛋白 G (IgG ) 集中,浆液贝它内啡肽(-EP), 皮质醇(C) ,睾丸激素(T) ,血浆促肾上腺皮质的荷尔蒙(ACTH ) 和浆液 T 淋巴细胞子集 CD3+ 和 CD4+ 。到皮质醇(C) 集中的结果平均数浆液睾丸激素集中和他们的比率比在有非最优的健康地位的那些在健康的组是显著地更高的(P < 0.01 ) 。吝啬的浆液 CD3+ 集中比在健康的组在有非最优的健康地位的那些是显著地更高的(P < 0.05 ) 。结论减少了浆液睾丸激素 / 皮质醇比率可以是非最优的健康的一个客观指示地位。在 neuroendocrine 和免疫学的指示物的变化可以解释一些症状,包括不适和差的工作性能,对可归因坚持或在有非最优的健康的题目的 relapsing 疲劳地位。
OBJECTIVE: To investigate biological indicators of sub-optimal health status and provide means of objective assessment of sub-optimal health status.METHODS: We set the unified standards for diagnosing a SHS. We tested various laboratory indicators in 407 cases that we selected randomly from2807 subjects and collected 15 mL of fasting venous blood from each case. We measured serum immunoglobulin A(IgA) and immunoglobulin G(IgG) concentrations, serum beta endorphins(β-EP), cortisol(C), testosterone(T), plasma adrenocorticotropic hormone(ACTH) and serum T lymphocyte subsets CD3+ and CD4+.RESULTS: Mean serum testosterone concentrations and their ratio to cortisol(C) concentrations weresignificantly higher in the healthy group than in those with sub-optimal health status(P0.01).Mean serum CD3+ concentrations were significantly higher in those with sub-optimal health status than in the healthy group(P0.05).CONCLUSION: Decreased serum testosterone/cortisol ratio may be an objective indication of sub-optimal health status. Changes in neuroendocrine and immunological indicators may explain some of the symptoms, including malaise and poor work performance, attributable to persistent or relapsing fatigue in subjects with sub-optimal health status.