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胃癌患者血清中exosome的水平及临床意义

ISSN号：1001-764X
期刊名称：《临床检验杂志》
时间：0
分类：R735.2[医药卫生—肿瘤;医药卫生—临床医学]
作者机构：[1]苏州大学附属第三医院肿瘤生物诊疗中心,江苏常州213000
相关基金：国家自然科学基金（81171653）; 江苏省自然科学基金（BK2011246,BK2011247）

关键词：胃癌, 外体, 血清, 酶联免疫吸附分析, gastric cancer, exosome, serum, enzyme linked immunosorbent assay

中文摘要：

目的探讨胃癌患者血清中外体（exosome）的水平及其临床意义。方法用ELISA法检测77例胃癌患者、34例体检健康者血清中EXOSC2（exosome component 2）的含量,以评估血清中exosome的水平,并分析其与胃癌患者临床病理特征的关系。结果胃癌患者血清中EXOSC2含量为[670.92（572.49,1 287.59）]pg/mL,健康对照组为[585.49（493.63,862.10）]pg/mL,两组间差异有统计学意义（P〈0.05）。胃癌患者中,淋巴结转移组血清中exosome水平明显高于无淋巴结转移组（P〈0.01）;Ⅲ、Ⅳ期exosome水平明显高于Ⅰ、Ⅱ期（P〈0.05）;低分化组水平明显高于高分化组（P〈0.05）。胃癌患者不同年龄、性别、肿瘤浸润深度、有无远处转移和肿瘤大小间exosome水平差异无统计学意义（P〉0.05）。结论胃癌患者血清中exosome水平的升高与肿瘤淋巴结转移、TNM分期及分化程度有关,测定血清中exosome的水平有助于判断胃癌的进展。

英文摘要：

Objective To investigate the serum exosome level in gastric cancer patients and its clinical significance. Methods The levels of serum exosome component 2（EXOSC2） in 77 patients with gastric cancer and 34 healthy controls were determined by ELISA.Then,the correlation of serum exosome levels with clinicopathological features of gastric cancer was analyzed. Results The serum exosome level [median（P25,P75）]in gastric cancer patients[670.92（572.49,1 287.59） pg/mL]was significantly higher than that in healthy controls [585. 49（493. 63,862. 10） pg /mL]（P〈0. 05）. The serum exosome level in gastric cancer patients with lymph node metastasis was significantly higher than that without lymph node metastasis（ P〈0. 01）. The serum exosome levels in gastric cancer patients with stages Ⅲ and Ⅳ were significantly higher than that with stages Ⅰ and Ⅱ（P〈0. 05）,and the poorly differentiated higher than the well-differentiated（P〈0. 05）. The serum exosome level was not related to the age,gender,depth of invasion,distant metastasis and tumor size of gastric cancer patients（ P〉0. 05）. Conclusion The increased serum exosome level in gastric cancer patients was related to lymph node metastasis,TNM staging and differentiation degree,suggesting that the serum exosome level may be helpful for evaluating the progress of gastric cancer.

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