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中文摘要：
MicroRNAs(miRNAs) are small,non-coding single-stranded RNAs that can modulate target gene expression at posttranscriptional level and participate in cell proliferation,differentiation,and apoptosis.T cells have important functions in acquired immune response;miRNAs regulate this immune response by targeting the mRNAs of genes involved in T cell development,proliferation,differentiation,and function.For instance,miR-181 family members function in progression by targeting Bcl2 and CD69,among others.MiR-17 to miR-92 clusters function by binding to CREB1,PTEN,and Bim.Considering that the suppression of T cell-mediated immune responses against tumor cells is involved in cancer progression,we should investigate the mechanism by which miRNA regulates T cells to develop new approaches for cancer treatment.
英文摘要：
MicroRNAs （miRNAs） are small, non-coding single-stranded RNAs that can modulate target gene expression at post- transcriptional level and participate in cell proliferation, differentiation, and apoptosis. T cells have important functions in acquired immune response; miRNAs regulate this immune response by targeting the mRNAs of genes involved in T cell developmentp proliferationj differentiationp and function. For instancep miR-181 family members function in progression by targeting Bcl2 and CD69, among others. MiR-17 to miR-92 clusters function by binding to CREB 1, PTEN, and Bim. Considering that the suppression ofT cell-mediated immune responses against tumor cells is involved in cancer progression, we should investigate the mechanism by which miRNA regulates T cells to develop new approaches for cancer treatment.
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