中文摘要：

目的：探讨玉米须多糖（PCS）对环磷酰胺（CTX）化疗H22荷瘤小鼠的减毒增效作用。方法：通过建立H22腹水瘤及实体瘤模型,评价PCS不同剂量（100、200、300 mg/kg）对H22荷瘤小鼠肿瘤生长的影响;评价PCS（300mg/kg）联合CTX（30 mg/kg）对H22荷瘤小鼠瘤质量、生存时间、脾脏指数、胸腺指数、外周血白细胞数、骨髓有核细胞、血清ALT及AST水平的影响。结果：PCS高剂量（300 mg/kg）具有显著的抑瘤作用。与CTX联用后对H22腹水瘤荷瘤小鼠的抑瘤率为68.71%,生命延长率为72.07%,抑瘤作用显著强于CTX（52.38%、47.19%）;联合用药时Q值为0.997,具有协同抗肿瘤作用。联合用药还可显著升高CTX致降低的脾脏指数、胸腺指数、外周血白细胞数及骨髓有核细胞;降低CTX致升高的ALT及AST水平。结论：PCS对H22荷瘤小鼠具有明显的抗肿瘤作用,与CTX联用后有增效减毒作用。

英文摘要：

Objective： To study the protective effect of polysaccharides from corn silk（PCS） against cyclophosphamide（CTX） induced host damages in mice bearing H22 tumors. Methods： The ascitic and solid tumor bearing mice model were established to investigate the anti-tumor effects of different dose of PCS（100,200 and 300 mg/kg）. The effects of PCS alone and with combination of CTX on tumor weight,survival time,thymus and spleen index,white blood cell,nucleated cell of marrow,serum ALT and AST level were tested. Results： The high-dose PCS（300 mg/kg） had significant inhibitory effects on tumor. After combination with CTX,the tumor inhibitory ratio was enhanced to 68. 71%,the survival time of tumor-burdened ascites tumor mice was significantly prolonged to 72. 07%compared with CTX group. The Q value of combination group was 0. 997. Thymus and spleen index,white blood cell,nucleated cell of marrow decreased by CTX were ameliorated significantly. The level of ALT and AST increased by CTX were reduced by combination with PCS. Conclusion： PCS has a potent inhibitory effect on the growth of implanted H22 tumors in mice and has a synergetic effect and an attenuated toxic effect in combination with CTX.