中文摘要：

蛋白质 HTRP (人的抄写管理者蛋白质) 被微分基因 htrp 编码并且在疱疹单一的病毒类型 1 导致了(HSV-1 ) 在 KMB-17 房间的感染。HTRP 被发现与 SAP30 (mSin3A 协会蛋白质) 交往，合作抑压者建筑群 mSin3A 的部件之一，它是 deacetylation 转移酶 HDAC 的部分。揭示在 HTRP 和 SAP30 之间的相互作用的生物意义，真实 -- 时间 PCR 和一个双酶的检测系统被使用。结果显示 HTRP 能禁止一个病毒的倡导者，其和 SAP30 的相互作用 synergistically 影响病毒的基因的 transcriptional 抑制，并且与 HDAC 酶活动有关的抄写。薄片实验证明 HTRP 能由增加在 histone 的离氨酸 14 和离氨酸 9 H3 的 deacetylation 水平支持 HDAC 活动。

英文摘要：

The protein HTRP （human transcription regulator protein） is encoded by the differential gene htrp and induced by Herpes simplex virus type 1 （HSV-1） infection in KMB-17 cells.HTRP was found to interact with SAP30 （mSin3A Association Protein）,one of the components of co-repressor complex mSin3A,which is part of the deacetylation transfer enzyme HDAC.To reveal the biological significance of the interaction between HTRP and SAP30,real-time PCR and a dual-luciferase detecting system was used.The results indicate that HTRP could inhibit the transcription of a viral promoter,whose interaction with SAP30 synergistically affects transcriptional inhibition of the viral genes,and is related to HDAC enzyme activity.ChIP experiments demonstrate that HTRP could promote HDAC activity by increasing the deacetylation level of lysine 14 and lysine 9 in histone H3.