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颌面部触觉及热刺激痛时大脑皮层激活区定位方法的初步探讨
  • 期刊名称:口腔颌面修复学杂志,7(2);2006:87-90
  • 时间:0
  • 分类:R783[医药卫生—口腔医学;医药卫生—临床医学]
  • 作者机构:[1]解放军总医院口腔科博士生,北京100853, [2]解放军总医院口腔科主任主任医师教授,北京100853, [3]解放军第三零六医院放射科磁共振室医师,北京100101, [4]解放军第三零六医院放射科磁共振室主任医师教授,北京100101
  • 相关基金:国家自然科学基金(30572066)首都医学发展科研基金重点项目(2003.2018)
  • 相关项目:口腔咀嚼功能及咬合改变与脑功能关系的研究
中文摘要:

目的:探讨将功能性磁共振成像(fMRI)技术运用于颌面部触觉及痛觉的大脑皮层定位研究的可行性。方法;选取右利手正常志愿者1名,分别采用触觉、热痛刺激颌面部及组块设计方法,采集全脑fMRI扫描数据,并用SPM99软件包进行结果的数据分析获得脑功能成像。结果:触觉刺激任务引起左侧顶叶中央后回(BA3)、右侧顶叶中央后回(BA1)、左额叶中央前回、右侧颞上回激活。热刺激痛任务可见右侧顶叶中央后回、右额叶中央前回、左侧额叶中央前回、左额上回、左前扣带回、左边缘叶前扣带回激活。结论:fMRI技术在合适的刺激条件下,可用于探讨颌面部触觉、疼痛与脑功能关系的研究,其脑激活区还有待于进一步实验结果。

英文摘要:

Objective: To primarily evaluate the feasibility of functional magnetic resonance imaging(fMRI) on the location of brain regions related to maxillothcial tactile and heat stimulated pain. Methods: A right handed healthy volunteer was selected to perform the fMRI study. Tactile and noeiceptive heat stimuli were applied separately to maxillofacial region, and block designed BOLD functional MRI scan covering the whole brain was carried out. The fMRI data were analyzed by SPM99 software to generate the activation map. Results: Tactile and pain induced by heat stimulation were found to have different activation sites on brain cortex. Conclusion: fMRI may be used in exploring the relation between tactile and pain in maxillofacial region and brain function if proper stimulation methods are practiced. The exact brain regions need to be elucidated by further study.

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