中文摘要：

目的：探讨上颌骨缺损与完整牙列对照组,咀嚼运动前后脑血流变化的差异性。方法：选取因肿瘤手术切除导致上颌骨缺损的患者16例,另选择16名完整牙列志愿者为对照组,应用经颅多普勒超声探测仪,测量两组在不咀嚼、空咀嚼5min、10min三个时段的大脑中动脉（MCA）收缩期峰流速（Vs）、舒张期末峰流速（Vd）、平均峰流速值（Vm）。采用SPSS 13.0进行重复测量数据的方差分析。结果：两组实验对象Vs、Vd、Vm的差异均有统计学意义（P〈0.05）,在各时间段上对照组的峰流速高于病例组。时间因素对Vs、Vd、Vm的影响有统计学意义（P〈0.05）。随着咀嚼时间的延长,峰流速均数增加。时间因素与缺损因素对Vs、Vd、Vm的影响有交互作用（P〈0.05）。结论：与完整牙列受试者相比,上颌骨缺损患者咀嚼运动时大脑中动脉血流量一定程度减少。咀嚼运动可显著提高完整牙列受试者大脑中动脉血流流速,增加相应脑区供血量,且随咀嚼运动时间延长（累计咀嚼10min）脑血流速呈加快趋势。

英文摘要：

Objective： To investigate the difference of the cerebral blood flow between the maxillary defect and the control group. Methods： 16 patients with maxillary defect due to tumor resection were selected, and 16 complete dentition persons were selectedas control group. Shrink of peak velocity（Vs）, end-diastolic peak velocity（Vd）, average peak velocity values（Vm） of middle cerebral artery（MCA） were measured by transcranial Doppler ultrasound detector. Twogroups were measured on the following 3 time points： 0min, 5min, 10 min after empty mastication. Variance for repeated measures data was analyzed with SPSS 13.0. Results： There was significant difference in Vs, Vd and Vm between two groups（P〈0.05）. The peak velocity of the control group was higher than that of the patients group at each time point. Time factors had significant impact to Vs, Vd（P〈0.05）, As mastication time increased, the mean peak velocity increased. The influence of time factor and defect factor on Vs, Vd and Vmwas statistically significant（P〈0.05）. Conclusion： Compared with the complete dentition persons, Cerebral blood velocity during mastication in maxillary defect patients decreases. The chewing movement can significantly increase cerebral blood velocity of MCA, and then increase the blood supply of the corresponding brain region.The cerebral blood velocity is accelerated with the chewing time increasing（total chewing 10min）.