中文摘要：

目的利用功能性磁共振成像探讨人类高级神经中枢如何解读已知即将到来的牙痛刺激。方法选取右上颌前磨牙牙髓冷刺激痛患者8名，采用牙痛期待过程（期待信号减静息信号）和牙痛体验过程（牙髓冷刺激痛信号减静息信号）的组块设计方法，采集功能性磁共振成像扫描数据并用SPM2软件包进行结果的数据分析。结果在牙痛期待过程中左侧额、下回的BA10和BA46，中央后回的第一躯体感觉皮层BA2、BA3，额中回BA8，中央前回的BA44，中脑和右侧小脑可以见到信号的增强。结论牙痛期待本身而非实际的牙髓刺激痛就可以激活大脑皮层的相关区域；牙痛期待过程的皮层反应集中于前额皮质、第一躯体感觉皮层、辅助运动皮质和小脑，与以往有关疼痛期待的研究结果类似；对疼痛期待所产生的感觉、情绪、认知及运动的皮层兴奋，证明大脑伤害性信息网络是直接受到暗示影响的。

英文摘要：

Objective To reveal functional activity mapping during anticipation of dental pain with non-invasive fMRI technique, and to offer therapeutic possibilities for treating chronic oral facial pain psychologically. Methods 8 right handed patients with dentinalgia of the right maxillary bicuspid were included in this study. Block design was adopted, BOLD level during anticipation epoch （on） was contrasted with that of rest （off）. Functional MRI scan covering the whole brain was carried out. The fMRI data were analyzed by SPM2 software with t-test to generate the activation map. Results Increased BOLD signals during dental pain anticipation were found dominantly on the left side in inferior, middle frontal gyrus/BA10,46, pestcentral gyrus/BA2,3, middle frontal gyrus/BA8, precentral gyrus/BA44 and cerebellum. Conclusion Anticipation of dental pain by itself can activate brain regions, especially prefrontal areas, SI, SMA and cerebellum. The results of pain anticipation are consisted with previous studies except that there is no activation in insula and cingulate cortex. Sensory, motor, cognitive and emotional activation in dental pain anticipation may indicate that brain nociceptive network can be affected by hint.