中文摘要：

角膜重建是对角膜组织遭受各种外伤、炎症、退行性疾病的影响后,进行角膜结构完整性及角膜功能的手术重建修复。角膜疾病在世界范围内造成了上百万人的视力损害甚至失明。当前角膜移植是角膜盲的主要治疗措施,然而供体角膜组织的短缺是一个世界性的难题,治疗后因为移植物受到宿主免疫排斥而造成的治疗失败也不罕见。如今随着组织培养和生物工程技术的进步,自体干细胞移植在再生医学中的应用前景越来越被人重视,它将有可能取代异体组织移植成为再生医学的重要临床治疗手段。人牙髓干细胞（human dental pulpstemcells,hDPSCs）是一类从人第三磨牙中分离出的成人干细胞,它和角膜细胞共同来源于胚胎外胚层的脑神经鞘。众多研究结果显示牙髓干细胞拥有向角膜细胞分化的潜能,并且不会引起受体的免疫排斥。这些发现显示了牙髓干细胞在眼表重建的相关临床应用中的潜力。本文就hDPSCs的特性及在角膜重建中的研究现状进行综述。

英文摘要：

The corneal reconstruction is tosurgial recover the structure integrity and corneal function after suffered from various trauma, inflammation and degenerative diseases. The corneal diseases caused millions of people worldwide suffering from eyesight damages and even blindness. At present, the corneal transplant is the main therapy for corneal blindness. However, the shortage in donor corneal issue is a worldwide problem and the failure due to the immunologic rejection of host is common. Nowadays, with the development of tissue culture and bioengineering technology, the application prospect of autologous stern cell transplantation is becoming more and more popular which might replace the allogeneic transplantation, becoming an important clinical treatment of regenerative medicine. Human dental pulp stern cells （hDPSCs） is a class of adult stem cell divided from the third molar teeth. Both hDPSCs and corneal cell are from the cranial nerve in embryonic ectoderm. Extensive researches show that the hDPSCs have the potentialities in corneal cell differentiation without causing immunologic rejection of the recipient. These findings manifested thepotentials of hDPSCs in the clinical applications related to ocular surface reconstruction. In this paper, the features and current investigation status of hDPSCs in ocular surface reconstruction are reviewed.