中文摘要：

目的：探讨p21^WAF1/CIP1基因第31位密码子多态性（p21 Ser31Arg）与新疆维吾尔族（维族）宫颈癌遗传易感性的关系.方法：采用限制性酶切片段长度多态性分析（PCR—RFLP）技术检测100例维族宫颈癌及100例维族正常宫颈组织中D21 Ser31Arg的分布，分析两者之间的相关性结果：1）宫颈癌组中p21 Ser31Arg三种基因型检出率分别为Arg／Arg 13．0％、Ser／Ser 38．0％、Arg／Ser 49．0％、对照组中三种基因型检出率分别为Arg／Arg10．0％、Ser／Ser 39．0％、Arg／Ser 51．0％，两组基因型构成比经统计学分析差异无显著性（x^2=0．444，P〉0．05）。2）p21 Ser31Arg多态性在中分化和低分化鳞癌组之间的构成比差异有显著性（x^2=6．560，P=0．038）。3）p21 Ser31Arg多态性与年龄分组无相关性（X^2=0．341，P〉0．05）。结论：p21 Ser31Arg多态性可能与维族宫颈癌的遗传易感性无明显相关性，但多因素分层分析显示不同的基因型可能与宫颈癌不同的组织分化程度有关．但与年龄分组无关.

英文摘要：

Objective： To determine the distribution of p21 Ser31Arg polymorphism and correlate this polymorphism to genetic susceptibility to cervical carcinoma in Uygur women in Xinjiang. Methods： PCR, semi-nested PCR and PCR-RFLP were performed to detect the p21 Ser31Arg genotype distribution in 100 cases of cervical carcinoma and 100 normal cases. Results： 1） The frequency of Arg/ Arg, Ser/Ser and Arg/Ser was 13.0%, 38.0% and 49.0%, respectively, in the cervical carcinoma cases and 10.0%, 39.0% and 51%, respectively, in tile control cases. Differences in genotype frequencies between the cervical carcinomas and the controls was not statistically significant （x^2= 0.444, P〉0.05）. 2） The genotype frequencies in well-differentiated squamous cell carcinoma were significantly different from those found in poorly-differentiated squamous cell carcinoma （x^2=6.560, P=0.038）. 3） No significant difference in p21 Ser31Arg polymorphism frequency was observed across various age groups （x^2= 0.341, P〉0.05）. Conclusion： The p21 Ser31Arg polymorphism may not be associated with cervical carcinoma in Uygur women in Xinjiang, but muhifactorial laminate analysis shows that the different genotypes are related to different types of cervical carcinoma but not related to patient age.