中文摘要：

GaddA5基因是Gadd（growth arrest and DNA damage-indueible genes）生长抑制及DNA损伤诱导基因家族的一员，是电离辐射效应基因之一，在细胞周期控制、DNA损伤修复及细胞信号转导过程中发挥重要作用，但更重要的是它是凋亡诱导基因，在肿瘤细胞凋亡中起级联桥梁作用。其家族成员的组织表达特异性、信号传导特异性以及功能的差异导致该基因在肿瘤细胞存活、凋亡信号通路中发挥错综复杂的作用。

英文摘要：

Gadd45 is one of Gadd （growth-arrest and DNA damage-inducible genes） gene family. It＇ s also a gene induced by ionization radiation. It plays an important role in controlling cell cycle, repairing damaged DNA and in the process of cell signal transduction, but more importantly it induces cell apoptosis and is a bridge in the cascade process of apoptosis of tumor cell. At the same time, the function of all members of C, add45 family is determined by the expression specificity of tissues and the difference of cell signal tranduction.