中文摘要：

RASSFiA（ras association domain family 1 agene）是RAS相关结构域家族似S5F1基因的转录本A，它编码一组RAS效应蛋白，它的启动子高甲基化及其基因外失活已在多种人肿瘤细胞株和原发性癌组织中普遍存在，它在多种恶性肿瘤的发生和诱导细胞凋亡的过程中发挥作用。

英文摘要：

Ras association domain family 1 agene （RASSF1A）is transcript A of gene RASSF1. It encodes a set of effector protein of RAS. Promoter hypermethylation of RASSF1A and inactivation of RASSF1A are very popular in many tumor cell line and primary tumor tissue. It plays an important role in the formation of various malignancy tumors and inducing apoptosis of cells.