中文摘要：

将凹凸棒黏土（ATP）与海藻酸钠（SA）进行复合以改善SA的缓释性能。以ATP/SA复合物为球芯材料，壳聚糖（CS）为包覆材料，采用复凝聚法制备凹土/海藻酸钠/壳聚糖复合微球（ASCM），并以双氯芬酸钠（DS）为模型药物，考察了凹土添加量对复合微球溶胀性能、载药性能和缓释性能的影响。结果表明，凹土的加入改善了微球的溶胀性能和缓释性能，而对微球载药性能影响不大。与海藻酸钠/壳聚糖微球（SCM）相比，当复合微球中ATP/SA（w/w）为20%时，其在pH6.8的磷酸缓冲溶液中2 h的累积释放率由58.8%减小到38.7%。复合微球体外释放动力学数据表明，其释药行为可以很好地用一级动力学方程拟合。凹土的加入有效改善了SA的缓释性能，ASCM可作为缓释药物的载体材料。

英文摘要：

Attapulgite （ATP） was composited with sodium alginate （SA） to improve the sustained release properties of SA. Attapulgite/sodium alginate/chitosan composite microspheres （ASCM） were prepared by complex coacervation using ATP/SA composites as the core material of the microspheres and chitosan （CS） as the coating material. The effects of ATP on swelling, drug loading and sustained release of ASCM were investigated with diclofenac sodium （DS） as a model drug, and the optimum amount of ATP were obtained. The results show that ASCM exhibits excellent swelling and sustained release ability. Compared with sodium alginate/chitosan microspheres （SCM）, the cumulative release of DS from ASCM （20 %（wt） ATP/SA （w/w）） decreased from 58.8% to 38.7% after 2 h in phosphate buffer solution at pH 6.8. The study of drug release kinetics shows that the releasing processes are better fitted by first-order release kinetic model. The incorporation of ATP in microspheres improves the releasing performance of SA, and ASCM can be used as a potential sustained release carrier.