中文摘要：

以海藻酸钠（SA）和酸化凹凸棒石（H＋-ATP）为原料，运用溶液共混法制备了一种具有优良缓释性能的复合材料，并以其为基质材料制备了双氯芬酸钠（DS）缓释片。利用SEM、FTIR和XRD对复合材料形貌和结构进行了表征，考察了酸改性剂浓度、H＋-ATP用量和复合时间对复合材料缓释性能的影响，以获得最佳复合工艺。结果表明，当用12 mol·L^-1盐酸酸化的ATP量占复合物总量60%时，复合缓释片在体外模拟肠液中缓释性能最佳。与单一海藻酸缓释片相比，复合缓释片2 h的累积释放率由42.6%下降到23.7%，有效改善了“突释”效应。释放动力学研究表明，复合缓释片的释药行为可以用Ritger-Peppas方程很好地拟合，释药速率受骨架溶蚀和药物扩散双重控制。H＋-ATP的加入显著改善了海藻酸的缓释性能。

英文摘要：

A composite material with improved sustained release properties, based on hybridization of sodium alginate （SA） and acidified-attapulgite （H＋-ATP ）, was prepared by solution mixing and was developed for drug carrier. Diclofenac sodium （DS） was selected as the model drug to obtain release data from the composite-based matrix tablets in phosphate buffer solution （PBS）in vitro. The morphology and structure of the composite were characterized by FTIR, SEM and XRD. The effect of content of acid modifier, H＋-ATP content and mixing time on the slow release properties of the composite were investigated to obtain optimum process condition. The composite with 60% H＋-ATP treated by 12 mol·L^-1 HCl exhibited perfect release properties. Compared with pure alginate tablets, the burst release of 42.6 % in 2 h decreased to 23.7% for the prepared composite. The drug release process of the composite was better fitted by the Ritger-Peppas model and the rate of drug release was governed by both diffusion and swelling mode. The introduced H＋-ATP improved the release properties of alginate significantly.