中文摘要：

运用PCR及PCR-RFLP技术检测p53Arg72Pro和p21Ser31Arg多态性在新疆维吾尔族（维族）宫颈癌中的分布，探讨其与维族宫颈癌发生的相关性。结果显示：p53基因型Arg/Arg、Pro／Pro、Arg/Pro在维族宫颈癌中的分布为46.0％、13.2％、40．8％，对照组为30．0％、14．5％、55。5％，两组构成比差异有显著性（x^2=7．196,P〈0．05）；p21基因型Arg／Arg、Ser／Ser、Arg／Ser在维族宫颈癌中的分布为13．0％、38.0％、49.0％，对照组为10.0％、39．0％、51．0％，两组构成比差异无显著性（x^2=0．444，P〉0．05）。提示p53Arg/Arg基因型可能是维族宫颈癌发生的遗传易感因素；p21Ser31A职多态性可能与维族宫颈癌的遗传易感性无关。

英文摘要：

Using PCR and PCR-RFLP methods, to determine the distribution of p53 Arg72Pro, p21Ser31Arg polymorphism and correlate this polymorphism to genetic susceptibility in cervical carcinoma in Uigur women in Xinjiang. Resuhs： 1）frequencies of Arg/Arg, Pro/Pro and Arg/Pro in p53 were 46.0%, 13.2% and 40.8% in 152 cases of cervical carcinoma and 30.0%, 14.5 % and 55.5 % in control cases, respectively. The omni-constituent ratio was statistically dif- ferent between cervical carcinoma and normal control （X^2 = 7. 196, P 〈 0.05）. 2） Frequencies of Arg/Arg, Ser/Ser and Arg/.. Set in p21 were 13.0% ,38.0% and 49.0% in 100 cases of cervical carcinoma and 10.0% ,39.0% and 51% in control cases respectively. Difference of genotype frequencies between the cervical carcinomas and the Controls was not significant statistically （X^2= 0.444, P 〉 0.05）. Conclusions： 1 ）p53 Arg/Arg genotype may be a genetic susceptible factor in cervical carcinoma in Uigur women. 2）p21Ser31Arg polymorphism may not be associated with cervical carcinoma in Uigur women in Xinjiang.