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中文摘要：
帕金森病（Parkinson disease,PD）是常见的神经变性疾病,除静止性震颤、运动迟缓、肌强直、步态和姿势障碍等运动症状外,近年研究发现其还存在神经精神、睡眠、感觉及自主神经障碍等多种非运动症状。PD单纯淡漠是不伴痴呆和抑郁的淡漠,其与运动症状及多种非运动症状相关,严重影响患者的日常生活能力及生活质量。PD单纯淡漠的发生涉及神经解剖、神经病理、神经生化及神经免疫炎症等机制。本文将对PD单纯淡漠的临床特征及发生机制进行阐述。
英文摘要：
Parkinson disease（ PD） is a common neurodegenerative disease characterized by classical motor symptoms,including static tremor,bradykinesia,rigidity and postural and gait abnormalities. Besides,recent studies have found a variety of non-motor symptoms,including neuropsychiatric symptoms,sleep disorders,abnormal sensory and autonomic dysfunctions,etc. PD with pure apathy,referring to apathy without dementia and depression,is correlated with motor symptoms and other non-motor symptoms,and greatly reduces the activity of daily living and the quality of life for PD patients. The pathogenesis of PD with pure apathy involves the mechanisms of neuroanatomy,neuropathology,neurological biochemistry and neuroinflammation. This paper will introduce the clinical features and pathogenic mechanisms of PD with pure apathy.
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