中文摘要：

目的 探讨帕金森病（PD）伴发轻度认知障碍（PD-MCI）的特点、相关因素及其对生活质量的影响.方法 收集2010年4月至2011年8月就诊于北京天坛医院神经内科的122例帕金森病患者的人口学资料;完成Hoehn-Yahr分期、帕金森病统一评定量表第Ⅱ部分（UPDRS-Ⅱ）及第Ⅲ部分（UPDRS-Ⅲ）、临床痴呆评定量表（CDR）、简易精神状态量表（MMSE）、蒙特利尔认知评估量表（MoCA）、汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）、爱泼沃斯思睡量表（ESS）、疲劳量表（FS-14）、日常生活能力问卷（ADL）及39项帕金森病生活质量问卷（PDQL-39）的评测.结果 （1）根据量表评测结果,122例PD患者中67例为轻度认知功能障碍（PD-MCI组）,占54.92%,47例为无认知功能障碍（PD-NCI组）,占38.52%;（2）PD-MCI组与PD-NCI组MoCA评分分别为（19.93±3.50）分和（26.74±1.48）分,有统计学差异（P=0.00）;（3）PD-MCI组与PD-NCI组各认知域得分比较如下：视空间与执行功能（2.43±1.62）分和（4.06±0.97）分,命名（2.69±0.61）分和（2.98±0.15）分;注意力与计算力（5.01±1.16）分和（5.87±0.49）分;语言（2.19±0.88）分和（2.83±0.38）分;抽象思维（0.93±0.8）分和（1.74±0.57）分;延迟记忆（1.19±1.26）分和（3.28±1.23）分;定向力（5.49±0.84）分和（5.89±0.48）分,PD-MCI组注意力与计算力、延迟记忆、视空间及执行功能的得分明显低于PD-NCI组（P值分别为0.00、0.00和0.00）;（4）人口学因素：PD-MCI组与PD-NCI组受教育时间分别为（8.51±0.53）年和（11.86±0.51）年,有统计学差异（P=0.00）;年龄、起病年龄、病程及性别比例无统计学差异;（5）PD-MCI组与PD-NCI组运动功能比较：Hoehn-Yahr分期为（2.29±0.09）期和（2.00±0.10）期;UPDRS-Ⅲ评分为（27.76±1.31）分和（23.62±1.56）分,有统计学差异（P值分别为0.03和0.04）;（6）PD-MCI与PD-NCI组非运动?

英文摘要：

Objective To investigate the features and related factors of Parkinson＇s disease（PD） with mild cognitive impairment（PD-MCI） and its impact on the quality of life for PD patients. Methods 122 PD patients were recruited and collected for the general information. The patients were evaluated by Hoehn-Yahr stage, Unified Parkinson＇s Disease Rating Scale （UPDRS）Ⅱ and Ⅲ, Clinical Dementia Rating （CDR）, Mini-Mental State Examination（ MMSE）, Montreal Cognitive Assessment（ MoCA）, Hamilton Anxiety Rating Scale（ HAMA）, Hamilton Depression Rating Scale （ HAMD ）, The Epworth Sleepiness Scale （ ESS）, Fatigue Scale （ FS-14 ）, Ability of Daily Living Questionnaire（ADL） and Parkinson＇s Disease Quality of Life Questionnaire-39 （PDQL-39）. Results （ 1 ） 67 cases in 122 PD patients（54.92% ）were with mild cognitive impairment（PD-MCI） and 47 cases（38.52% ）were with no cognitive impairment（PD-NCI） ;（2）MoCA scores of PD-MCI and PD-NCI groups were 19. 93 ± 3.50 vs. 26. 74±1. 48, and the difference was statistically significant （ P = 0.00） ; （ 3 ） Scoring rates of each cognitive domain in PD- MCI and PD-NCI groups were as followed： visuo-spatial and executive function ： 2.43 ± 1.62 vs. 4. 06 ± 0. 97, naming ：2. 69 ± 0. 61 vs. 2. 98± 0. 15, attention and calculation： 5.01 ± 1, 16 vs. 5.87± 0.49, language ： 2. 19 ± 0. 88 vs. 2. 83±0. 38, abstraction ：0. 93 ±0. 88 vs. 1.74± 0. 57, delayed memory ： 1.19 ± 1.26 vs. 31 28± 1.23, orientation ： 5.49 ±0. 84 vs. 5.89±O. 48 ; Among which, scoring rates of attention and calculation, delayed memory, visuo-spatial and executive function in PD-MCI group were significantly higher than that in PD-NCI group （ P = 0. 00,0. 00 and 0. O0,respectively）;（4）The course of education in PD-MCI and PD-NCI groups were （8.51 ± O. 53 ）years vs. （ 11.86 ± 0. 51 ） years, and the difference was statistically significant （ P = 0. 00） ; the differences of age of onset, age, the course