中文摘要：

目的探讨帕金森病（PD）患者伴发焦虑与运动症状及非运动症状（NMS）的关系。方法对124例PD患者应用汉密尔顿焦虑量表（HAMA）进行评测，分为焦虑组和非焦虑组，并完成相关运动症状及NMS量表评测。结果（1）124例PD患者焦虑发生率为33．87％，焦虑和抑郁共病率为31．45％；（2）两组患者运动症状及运动并发症相关量表评测结果分别为：Hoehn-Yahr分期：2．48±0．80vs．2．04±0．78；UPDRS-Ⅲ（运动）：30．68±9．91vs．24．70±12．25；“开-关”现象发生率：35．71％vs．17．07％，两组间具有统计学差异（P〈0．05）；两组患者异动症发生率及剂末现象的发生率分别为：14．29％vs．7．32％、45．24％vs．30．49％，两组问无统计学差异（P〉0．05）；（3）焦虑组患者出现NMS个数为（14．57±3．83）个，非焦虑组患者为（10．03±5．25）个，两组间均有统计学差异（P〈0．05）；（4）焦虑组抑郁、性生活障碍、不宁腿综合征、淡漠、白天思睡、入睡困难、眩晕、疼痛、噩梦以及体位性头晕等NMS发生率高于非焦虑组，两组均有统计学差异（P〈0．05）；（5）焦虑组和非焦虑组患者NMS相关量表评测结果分别为：UPDRS-Ⅰ（精神、行为和情绪）：4．74±1．93vs．2．93±1．84；HAMD：19．41±6．97vs．9．82±5．83；PSQI：19．48±6．36vs．12．37±6．47：ESS：6．69±5．62vs．3．56±3．34；SCOPA-AUT：43．48±7．75vs.36．76±7．33；RLSRS：21．77±6．51vs．17．29±7．27，两组间具有统计学差异（P〈0．05），两组患者的MMSE、MoCA及Fs-14评分分别为：26．12±4．37vs．27．16±3．28、21．05±6．38vs.22．71±4．67及10．71±2．69vs．9．42±3．26，均无统计学差异（P〉0．05）；（6）焦虑组和非焦虑组患者UPDRS-Ⅱ（日常生活活动）以及PDQL评分结果分别为：15．29±5．85vs．12．22±5．39、128．62±20．51vs．149．30±20．13

英文摘要：

Objective To explore the relationships between anxiety and the motor symptoms or non-motor symptoms（NMS）in patients with Parkinson＇s disease（PD）.Methods 124 PD patients were collected and divided into anxiety group and non-anxiety group according to the scores of Hamilton Anxiety Scale（HAMA）and a comparison study was conducted by using related motor symptoms and NMS scales.Results（1）33.87% of PD patients were accompanied by anxiety,31.45% of PD patients suffered from anxiety and depression synchronously.（2）Results of motor symptoms and movement complications in the two groups were as followed：Hoehn-Yahr Staging：2.48±0.80 vs.2.04±0.78,UPDRS-Ⅲ（motor）：30.68±9.91 vs.24.70±12.25,incidence of＂on-off＂phenomenon：35.71% vs.17.07%,and there were significant differences between the two groups（P0.05）;the incidences of dyskinesia and wearing-off were 14.29% vs.7.32% and 45.24% vs.30.49%,respectively,which were not statistically significant（P0.05）.（3）The number of NMS in anxiety group was 14.57±3.83,non-anxiety group was 10.03±5.25,and there was a significant difference between the two groups（P0.05）.（4）The incidences of depression,sexual dysfunction,restless legs syndrome,apathy,daytime somnolence,insomnia,dizziness,pain,nightmare and positional vertigo in anxiety group were higer than that in non-anxiety group,and there were significant differences between the two groups（P0.05）.（5）Results of NMS in anxiety group and non-anxiety group were as followed：UPDRS-Ⅰ（psychiatrics,cognition and emotion）：4.74±1.93 vs.2.93±1.84;HAMD：19.41±6.97 vs.9.82±5.83;PSQI：19.48±6.36 vs.12.37±6.47;ESS：6.69±5.62 vs.3.56±3.34;SCOPA-AUT：43.48±7.75 vs.36.76±7.33;RLSRS：21.77±6.51 vs.17.29±7.27,and there were significant differences between the two groups（P0.05）.The scores of MMSE,MoCA and FS-14 in two groups were：26.12±4.37 vs.27.16±3.28,21.05±6.38 vs.22.71±4.67 and 10.71±2.69 vs.9.42±3.26,respectively,and there were no significant differ