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新型糖基化酶AlkC和AlkD
  • ISSN号：1000-1336
  • 期刊名称：生命的化学
  • 时间：0
  • 页码：415-418
  • 分类：Q71[生物学—分子生物学]
  • 作者机构：[1]长沙理工大学化学与生物工程学院、长沙410114, [2]中国科学院上海有机化学研究所,上海200032
  • 相关基金：国家自然科学基金项目（20902103;20872169和20921091）; 上海市浦江计划人才项目（08PJ1411700）; 科技部重大研究计划项目（2009CB918600）资助
  • 相关项目：DNA甲基化损伤剪切修复酶识别DNA中损伤位点动力学机制核磁共振探讨
作者： 魏建科|关文|朱静|曹春阳|龚福春|
关键词： DNA糖基化酶, AlkC, AlkD, DNA glycosylase, AlkC, AlkD
中文摘要：

DNA糖基化酶是一类有着重要生物功能的蛋白质,广泛存在于原核生物和真核生物中。研究表明,DNA糖基化酶能够特异性地识别损伤碱基,再通过各种酶修复DNA。最近,科学家在筛选土壤中3-甲基腺嘌呤糖基化酶时,发现了三种基因AlkC、AlkD和AlkE,其中AlkC和AlkD是两种新基因。本文根据近年来的研究成果,对AlkC和AlkD两种碱基糖基化修复酶的结构和功能,以及AlkD的切除损伤DNA的核酸捕获机理进行了总结。

英文摘要：

Existing in prokaryotes and eukaryotes,DNA glycosylase is a kind of protein which has very important biological functions.They can recognize specific lesion bases in DNA and repair it by hydrolyzing C-N glycosidic bond of the damaged site in DNA.Recently scientists have discovered three genes,AlkC,AlkD and AlkE during screening 3-methyladenine DNA glycosylase in genomic libraries of the soil bacterium.Among them,AlkC and AlkD were discovered for the first time.In this paper,a detailed review on the research progress of DNA glycosylases,especially on the function and the structure of AlkC and AlkD,was made.A novel lesion capture mechanism of AlkD was also discussed.

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期刊信息
  • 《生命的化学》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国生物化学与分子生物学会
  • 主编：阮康成
  • 地址：上海岳阳路319号
  • 邮编：200031
  • 邮箱：smhx@sibs.ac.cn
  • 电话：021-54921091
  • 国际标准刊号：ISSN：1000-1336
  • 国内统一刊号：ISSN：31-1384/Q
  • 邮发代号:4-315
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:8895