中文摘要：

目的：探讨紫杉醇联合替吉奥治疗老年晚期胃癌的近期疗效、不良反应及生存期。方法：2010年1月至2012年12月共28例老年（年龄≥65岁）晚期胃癌患者,采用紫杉醇静脉化疗联合替吉奥胶囊口服化疗,具体治疗方案：紫杉醇135mg/m2静脉滴注,d1;替吉奥胶囊60mg（体表面积≥1.5m2）口服,每天2次,d1～14;28天为一周期,2个周期评价疗效。结果：28例患者均可评价疗效,CR0例,PR5例,SD21例,PD2例,有效率为17.8%,疾病控制率为95.4%,中位总生存时间为9.5个月。主要不良反应为骨髓抑制及手足综合征,以1～2级为主,无治疗相关并发症及死亡。结论：紫杉醇联合替吉奥治疗老年晚期胃癌疗效肯定,且不良反应较轻,老年患者可耐受,值得临床进一步观察研究。

英文摘要：

Objective： To explore the recent results of taxol combined with tegafur gimeracil and oteracil potassium capsules （TGO） in the treatment of the elderly with advanced gastric cancer, their adverse reactions and survival period. Methods： Twenty-eight elderly cases over 65 years old with advanced gastric cancer were treated with taxol combined with TGO from Jan. 2010 to Dec. 2012. Taxol was administrated by intravenous infusion at 135 mg/m 2 , d1 and TGO was orally taken twice daily at 60 mg （body surface area≥1.5 m2 ）, d1～14 for 28-days as a cycle. The efficacy was evaluated after two cycles. Results： All of 28 cases were able to be evaluated, in which there were 0 case of CR, 5 cases of PR, 21 cases of SD and 2 cases of PD. Their effective rate was 17.8%, and control rate 95.4%. The median overall survival time was 9.5 months. The main adverse reactions were myelosuppression and hand-foot syndrome in 1～2 grades, but there was neither complication nor death related to the treatment. Conclusion： The efficacy of taxol combined with TGO in the treatment of the elderly with advanced gastric cancer has been confirmed and their adverse reactions are slight. This therapy can be tolerated by the elderly and is worthy of further observation and study.