中文摘要：

目的研究莫诺苷对局灶性脑缺血再灌注大鼠纤维蛋白原（Fib）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）和凝血酶时间（TT）的影响。方法用线栓法制备大鼠局灶性脑缺血再灌注模型，造模后，分别给予莫诺苷低剂量（30mg／kg）、中剂量（90mg／kg）、高剂量（270mg／kg）连续灌胃7d，阿司匹林（ASA）为阳性对照药。使用试剂盒分别检测Fib、PT、APTT、TT指标的变化。结果与假手术组相比，模型组Fib含量显著增加（P〈0．001），PT、APTT、TT显著缩短（P〈0．001）；与模型组相比，莫诺苷能明显降低Fib含量（P〈0．01），延长PT、APTT、TT（P〈0．05）。结论莫诺苷具有对抗局灶性脑缺血再灌注大鼠凝血功能的作用。

英文摘要：

Objective To investigate the effects of morroniside on fibrinogen （Fib）, prothrombin time （PT）, activated partial thrombo- plastin time （APTT） and thrombin time （TT） in focal cerebral ischemia/reperfusion in rats. Methods The animal model was induced with oc- clusion of middle cerebral artery （MCAO） with suture embolus, and morroniside was then administered intragastrically at the dose of 30, 90 and 270 mg/kg for 7 d. Acetyl salicylic acid was taken as positive control drug. The content of Fib, and PT, APTT and TT were measured withrelated kits. Results Compared with the sham-operated group, the concentration of Fib significantly increased （P〈0.001） and PT, APTT and TT significantly shortened in the model group （1~〈0.001）; however, compared with the model group, morroniside significantly decreased Fib content （P〈0.01） and prolonged PT, APTT and TT （P〈0.05）. Conclusion Morroniside can antagonize the coagulation fi.mction in focal cerebral ischemia/reperfusion in rats.