中文摘要：

目的研究莫诺苷对大鼠局灶性脑缺血损伤后血液黏度的影响。方法Longa法制备大鼠局灶性脑缺血模型，造模雷，分别给予莫诺苷（30mg／kg、90mg／kg、270mg／kg）连续灌胃7d，通过全自动血流变仪和微量血浆测试装置检测其全血黏度和血浆黏度。结果与假手术组相比，模型组全血黏度和血浆黏度均显著升高（P〈0．001）；与模型组相比，莫诺苷各剂量组全血黏度和血浆黏度显著降低（尸〈0．001）。结论莫诺苷能有效减少大鼠局灶性脑缺血模型引起的血液黏度升高。

英文摘要：

Objective To explore the effect of morroniside on blood viscosity in focal cerebral ischemia/reperfusion in rats. Methods The animal model was induced with occlusion of middle cerebral artery （MCAO）, and morroniside （30 mg/kg, 90 mg/kg, 270 mg/kg） was then administered intragastrically for 7 d. Whole blood viscosity and plasma viscosity were detected with auto-hemorheological instrument and microplasma testing device. Results Compared with sham-operated group, both whole blood viscosity and plasma viscosity significant- ly increased in ischemic rats （P〈0.001）; however, morroniside reduced whole blood and plasma viscosity noticeably （P〈0.001）. Conclusion Morroniside can inhibit the increase of blood viscosity induced by focal cerebral ischemia/reperfusion in rats.