中文摘要：

目的观察莫诺苷对二磷酸腺苷（ADP）诱导的局灶性脑缺血再灌注大鼠血小板聚集指数的影响。方法用线栓法制备大鼠局灶性脑缺血再灌注模型。将48只Sprague—Dawley大鼠随机分为假手术组，模型组，莫诺苷低、中、高剂量组（30mg／kg、90mg／kg、270mg／kg）和阿司匹林组（10mg／kg）。利用透光比浊法检测大鼠血小板聚集率。结果与模型组相比，高剂量莫诺苷组血小板最大聚集率显著降低（P〈0．001）。结论莫诺苷具有抑制血小板聚集的作用。

英文摘要：

Objective To explore the effects of morroniside on platelet aggregation induced by adenosine diphosphate （ADP） in focal ce- rebral ischemia/reperfusion in rats. Methods 48 Sprague-Dawley rats were randomly divided into sham group, model group, morroniside dose groups （30 mg/kg, 90 mg/kg, 270 mg/kg） and acetyl salicilic acid （ASA） group （10 mg/kg）. The model of middle cerebral artery occlu- sion （MCAO） was established in all rats except the sham group. Born＇s turbidimetry was used to measure platelet aggregation rate in rats of MCAO model （in vivo）. Results Compared with the model group, the platelet aggregation decreased significantly in the morroniside high dose group （P〈0.001）. Conclusion Morronisidc has the effect of anti-platelet aggregation in focal cerebral ischemia/reperfusion in rats.