中文摘要：

循环肿瘤细胞（Circulating tumor cells,CTCs）是指释放到血液中的罕见肿瘤细胞,被认为是肿瘤血液转移的关键步骤之一.循环肿瘤细胞的检测对于肿瘤的诊断、治疗和预后判定都具有非常重要的意义,是目前肿瘤研究的热点之一.本文将从预测生物标志物、治疗反应、预后、血浆肿瘤DNA四个方面介绍循环肿瘤细胞临床应用的最新研究进展.

英文摘要：

Circulating tumor cells （CTCs）are defined as cells that have detached,spontaneously or as a result of clinical operations,from a primary tumor or its metastatic lesions and circulate in the peripheral blood.They are considered as the primary reason for postoperative recurrence and distant metastasis of malignant tumors.CTCs have a advantage in cancers diagnosis,treatment and prognosis.This articlere views recent circulating tumor cells advances in research on diagnoses,response to treatment,prognosis and plasma tumor DNA.