肿瘤的发生、发展及复发转移离不开肿瘤血管生成。肿瘤血管生成受血管生成刺激因子和血管生成抑制因子的共同调节。通过减少刺激因子生成或增强抑制因子的作用均可抑制血管生成,从而达到抑制肿瘤生长的目的。因此,血管生成因子成为肿瘤治疗研究的靶点,是当前分子靶向治疗研究的基础。
The occurrence and maintenance of tumor are related with the growth of tumor blood vessels. Tumor's angiogenesis is regulated by angiogenesis - stimulating factor and angiogenesis inhibitory factor. Can inhibit angiogenesis can be inhibited by reducing the generation of the stimulating factor or enhance the role of inhibitory factor. Therefore, the inhibition of tumor angiogenesis is becoming a new therapeutic target.