中文摘要：

观察幼龄厌食大鼠摄食中枢（下丘脑外侧区lateral hypothalamic area，LHA）和饱中枢（下丘脑腹内侧核ventromedial hypothalamic nuclear，VMN）神经元兴奋性的改变。用特制饲料喂养幼龄大鼠3周制备厌食模型，然后用细胞外记录法，记录大鼠LHA和VMN神经元的白发放电，观察其对电刺激胃迷走神经和静脉注射葡萄糖的反应，比较对照组和模型组间的差异。结果显示：模型组大鼠LHA神经元对胃迷走神经刺激的反应特征与对照组无显著性差异，而VMN神经元对胃迷走神经刺激的兴奋性反应时程延长（P〈0．01），刺激强度降低（P〈0．01）。模型大鼠中对胃迷走神经刺激有反应的LHA神经元的血糖敏感率降低，而那些对胃迷走神经刺激有反应的VMN神经元的血糖敏感率增加（P〈0．01）。以上结果表明：特制饲料改变LHA和VMN神经元对外周传入的摄食负反馈信号的敏感性，从而使LHA和VMN神经元共同作用，发出抑制摄食信号，从而导致了厌食的发生。

英文摘要：

To observe the change on the neuronal excitability in LHA and VMN of the immature anorexia rats. The anorexia model was establisbed by feeding the rats with special forage for 3 weeks. By using extracellular recording technique,we recorded the spontaneous discharge of LHA and VMN neurons of rat and observed the responses after stimulating gastric vagal nerve and intravenous glucose between the control and model groups. The results indicated that there was no significantly difference about the response of LHA neurons after gastric vagal nerve stimulation between the two groups. However, the duration of excitation responses of VMN neurons of the model group was signiticanfly longer than that of the control group after the gastric vagal nerve stimulation （ P 〈0.01 ）, and the required stimulation intensity decreased significantly（ P 〈0.01 ）. The glucose sensitiveness of the LHA neurons which responded to the gastric vagal nerve stimulation in model group decreased （ P 〈0.01 ） but increased in VMN neurons （ P 〈0.01 ）. Our study demonstrates that the special forage changes the sensitivity of LHA and VMN neurons to the peripheral signals and makes the LHA and VMN neurons work together to depress the appetite of the immature anorexia rats.