中文摘要：

中枢神经系统疾病与某些外周疾病具有共生的特点,由＂脑-肠轴＂介导的炎症信号在外周和中枢间的传递被认为是联系中枢系统疾病与外周炎症的重要途径,这一机制对于全面认识中枢神经系统疾病的发病机制以及相关疾病的预防和治疗具有重要意义。本文就＂脑-肠轴＂介导的炎症信号传递对神经精神疾病,尤其是抑郁症的影响及其机制进行了综述,并探讨了干预＂脑-肠轴＂炎症信号对于中枢神经系统疾病的预防和治疗的潜在前景。

英文摘要：

Accumulating evidence reveals a close linkage between the central nervous system disorders and the peripheral diseases.It is believed that the ＂brain-gut axis＂ mediated inflammatory signal transmission is an important pathway to link the brain disorders and peripheral inflammation.In this review,we discusse the potential mechanisms involved in the inflammatory signal transmission along the ＂brain-gut axis＂ and its influence on the subsequently developed neuropsychiatric disorders especially major depression.Also the potential strategies to intervene the inflammatory signal transmission along the ＂brain-gut axis＂ for the prevention and treatment of brain disorders are discussed in this paper.