肠黏膜炎是化疗过程中的一种常见不良反应,具有发生率高、危害大的特点,严重影响肿瘤患者的治疗及生活质量。研究表明化疗致肠黏膜炎的病理生理学机制复杂,目前药物可干预的环节较多,但疗效尚不确切。本文综述了化疗致肠黏膜炎的病因及可能机制,并对缓减化疗毒副作用的药物及其干预环节进行了总结概况。以期为该疾病的合理治疗及相关药物的开发提供参考。
Intestinal mucositis is a common adverse reaction during chemotherapy, which was with high incidence, toxic, serious impact on cancer treatment and quality of life. Studies show that the pathogenesis of intestinal mucositis induced by chemotherapy is complex, thus the current drug intervention strategies were more, but the curative effect is not exact. In this paper, we reviewed the etiology of intestinal mucosal inflammation induced by chemotherapyand its possible mechanism, and summarized the possible mitigation way to alleviate the chemotherapy induced side effects. From this paper, we could provide reference for the development of rational treatment of this disease and related drugs.