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中文摘要：
随着老龄化社会的日益加剧，阿尔茨海默病（Alzheimer Disease，AD）作为一种老年认知障碍性疾病，发病率持续增高，但目前其发病机理还不明确，至今无法根治。AD是一种与基因突变和环境密切相关的神经退行性疾病，一旦有临床症状则无法逆转。所以最近国际上热点是对该疾病的早期发现、干预，尤其关注无症状性临床前期AD（Preclinical Alzheimer disease，PCAD）的危险因素。而微量元素是一种关键的AD诱发因素。现以微量元素组学为切入点，阐述PCAD中微量元素组学稳态的重要意义，以期能对AD的治疗以及预防有一定的意义。
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