中文摘要：

一氧化氮的功能多样，其作用机制也是复杂而相互关联的，是多靶点、多机制同时作用的调控网络。除了经典的cGMP依赖的信号通路外，一氧化氮还能通过对蛋白质的半胱氨酸巯基进行蛋白质翻译后修饰而起作用。蛋白质巯基亚硝基化修饰（protein S-nitrosation）是活性氮对蛋白质半胱氨酸巯基的一种蛋白质翻译后修饰，在一氧化氮的作用机制中占有重要位置。本综述简要总结蛋白质巯基亚硝基化修饰的功能及作用机制。

英文摘要：

The mechanisms of nitric oxide are complicated, which are involved in the network of multiple targets and need further research. Besides the classic cGMP-dependent signaling pathway, nitric oxide can function through protein post-translational modification on protein cysteine. The formed -SNO is a modification called protein S-nitrosation, which plays important roles in the mechanism of nitric oxide functions. This review briefly summarizes the main function and mechanism of protein S-nitrosation.