中文摘要：

目的观察高摄铝状态下氟中毒大鼠大豆、硒粉、螺旋藻的干预效果。方法将断乳2周的SD纯系大鼠40只（雌雄各半）按体质量随机分为5组：对照组、高氟铝组、高氟铝加大豆组、高氟铝加硒组和高氟铝加螺旋藻组，每组8只。对照组食用非病区玉米加工的饲料（含氟5．20mg／L，含铝6．80mg／L），饮用自来水（含氟0．70mg／L，含铝0．20mg／L）。其余各组均食用以病区玉米为主加工而成的饲料（含氟110．00mg／kg，含铝19．70mg／L）．饮用自来水配制的高铝水（含氟0．70mg／L，含铝90．00mg／L）。高氟铝加大豆组在实验开始即添加大豆（大豆占饲料的30％），高氟铝加硒组和高氟铝加螺旋藻组在动物出现氟斑牙后饲料中分别添加硒（3．00mg／kg）、螺旋藻（1000．00mg／kg），实验期为22周。大鼠处死前收集24h尿液，用于尿氟、铝的测定；大鼠处死后取四肢骨用于骨氟、铝测定；电镜下观察大鼠股骨松质骨的超微结构变化。结果①骨氟：高氟铝组的骨氟[（204．07±63．78）mg／kg]高于对照组、高氟铝加大豆组、高氟铝加硒组和高氟铝加螺旋藻组[（30．06±6．11）、（54．12±14．56）、（30．44±5．02）、（105．08±21．07）mg／kg，t=0．62、0．53、0．62、0．35，P均〈0．01]；高氟铝加硒组骨氟低于高氟铝加螺旋藻组（t=0．27，P〈0．01）。②尿氟：高氟铝组尿氟[（4．52±3．09）mg／L]高于对照组[（0．89±0．37）mg／L，t=0．23，P〈0．01]，低于高氟铝加硒组[（10．38±1．58）mg／L，t=0．34，P〈0．01]；高氟铝加硒组尿氟高于高氟铝加大豆组、高氟铝加螺旋藻组[（5．56±1．69）、（4．38±3．36）mg／L，t=0．28、0．35，P均〈0．01]。③骨铝：对照组骨铝[（3．32±3．02）mg／kg]明显低于高氟铝组、高氟铝加大豆组、高氟铝加硒组和高氟铝加螺旋藻组[（374．21±56．11）、（118．20?

英文摘要：

Objective To study the intervention effect of the fluorosis with the high aluminum plus soybean, selenium powder, spiral algae. Methods Two week-long SD rats were randomly allocated into 5 groups bases on body weight with 8 in each group, respectively being control, the high fluoride aluminum,the high fluoride aluminum plus soybean, the high fluoride aluminum plus selenium and the high fluoride aluminum plus spiral algae group. The control group was fed with corn produced in non-endemic area containing 5.20 mg/L of fluoride and 6.80 mg/L of aluminum and tap water of fluoride 0.70 mg/L and aluminum 0.20 mg/L. Other groups were fed primarily with corn produced in the endemic area with the content of fluoride of 110.00 mg/L and aluminum of 19.70 mg/L and tap water with high aluminum also with fluoride of 0.70 mg/L and aluminum of 90.00 mg/L. The high fluoride aluminum plus soybean group was added soybean in the beginning of the experiment, approximately 30% of the total amount. Selenium （3.00 mg/kg） was given to the high fluoride aluminum plus selenium groups and spiral algae （1000.00 mg/kg） to the high fluoride aluminum plus spiral algae groups after dental fluorosis was formed. The experiment lasted for 22 weeks. In the end of the experiment 24-hour urine and bones of the limbs were collected to test the content of fluorine and aluminum. The uhrastrueture of femur spongiosa was observed under electron microscope. Results （1） Bone fluoride in high fluoride aluminum group[ （204.07 ± 63.78）mg/kgl was higher than that in the control group, high fluoride aluminum plus soybean group, high fluoride aluminum plus selenium group and high fluoride aluminum plus spiral algae group[ （30.06 ± 6.11）, （54.12 ± 14.56）, （30.44 ± 5.02）, （105.08 ± 21.07）mg/kg, t = 0.62,0.53,0.62,0.35, all P 〈 0.01], indicating that it was lower in high fluoride aluminum plus selenium group than high fluoride aluminum plus spiral algae group（t = 0.27, P 〈 0.01 ）. （2） The urinary fluoride levels in high