中文摘要：

目的探讨过量氟、铝及其联合作用对大鼠全血锌（Zn）、铁（Fe）、钙（Ca）、镁（Mg）、铜（Cu）的影响。方法48只SD大鼠按体质量随机分为4组：对照组、高铝组、高氟组、高氟铝组，饮水含铝量分别为0、90、0、90mg／L；饲料含氟量分别为5．2、5．2、106．0、106．0mg／kg，含铝量分别为6．8、6．8、19．7、19．7mg／kg；90d后原子吸收光谱分析法测定全血Zn、Fe、Ca、Mg、Cu水平。结果组间比较，全血含Zn、Fe、Mg、Cu量差异有统计学意义（F值分别为46．25、14．74、6．10、2．93，P〈0．05），而全血含Ca量未见明显改变（F=2．81，P〉0．05）。析因分析显示，高铝摄入明显降低全血含Zn、Fe、Mg量（F值分别为42．66、5．41、7．04，P〈0．05），高氟摄人明显降低全血含Zn、Fe、Mg、Cu量（F值分别为64．50、37．90、9．75、6．74，P〈0．05），氟铝联合对全血含Zn量有交互作用（F=31．59，P〈0．05），Fe、Ca、Mg、Cu均未见明显交互作用（F值分别为0．91、1．63、1．51、0．00，P〉0．05）。与对照组全血含Zn、Fe、Mg、Cu量[（131．30±13．86）μmol／L．（10．24±1．02）、（1．71±0．19）mmol／L，（20．43±4．42）μmol／L]比较，高铝组全血含Zn量[（90．84±9．98）μmol／L]明显降低（P〈0．05），高氟组全血含Zn、Fe、Mg量[（85．85±10．92）μmol／L，（8．49±0．68）、（1．52±0．13）mmol/L]也明显降低（P〈0．05），高氟铝组全血含Zn、Fe、Mg、Cu量[（82．82±11．00）μmol／L，（8．16±0．45）、（1．46±0．09）mmol／L，（15．69±2．38）μmol／L]均明显降低（P〈0．05）；与高铝组[（9．43±1．09）mmoL／L]比较，高氟铝组全血含Fe量[（8．16±0．45）mmol／L]明显降低（P〈0．05）。结论过量氟能引起全血含Zn、Fe、Mg、Cu量下降，过量铝能引起全血含Zn、Fe、Mg量降低；氟铝联合对大鼠全血含Ca量无影响。仅对?

英文摘要：

Objective To investigate the effect of excessive fluoride, aluminum on Zn, Fe, Ca, Mg, Cu in rat blood. Methods Forty eight SD rats were randomly divided into 4 groups matched with their weights： control group, high aluminum group, high fluorine group and high fluorine-aluminum group. Aluminum content in their drinking water was 0,90,0,90 mg/L respectively. Fluorine content of their feed was 5.2,5.2,106.0,106.0 mg/kg and aluminum was 6.8,6.8,19.7,19.7 mg/kg respectively. 90 days later, the level of blood Zn, Fe, Ca, Mg, Cu was detected by the atomic absorption spectrometry. Results Compared among these groups, Zn, Fe, Mg and Cu content of the whole blood had significant differences（F = 46.25,14.74,6.10,2.93, P 〈 0.05）, while Ca content of the whole blood did not significantly change（F = 2.81, P 〉 0.05 ）. Factorial analysis showed that excessive intake of aluminum could significantly decreased Zn, Fe, Mg content of the blood（F = 42.66,5.41,7.04, P 〈 0.05） and excessive intake of fluorine could significantly decreased Zn, Fe, Mg, Cu content of the blood（F = 64.50,37.90, 9.75,6.74, P 〈 0.05）. The coexistence of fluorine and aluminum had interaction to the level of Zn（F = 31.59, P 〈 0.05） and did not obviously interact with other elements（F = 0.91,1.63,1.51,0.00, P 〉 0.05）. Compared with the control group [ （131.30 ± 13.86）μmol/L, （10.24 ± 1.02）, （1.71 ± 0.19）mmol/L, （20.43 ± 4.42）μmol/L], Zn content in the high aluminum group[ （90.84 ± 9.98）lxmol/L] decreased significantly （P 〈 0.05）, so did Zn, Fe, Mg content in the high fluorine group [（85.85 ± 10.92）μmol/L, （8.49 ± 0.68）, （1.52 ± 0.13）mmol/L], the difference being statistically significant （P 〈 0.05 ）. Zn, Fe, Mg, Cu content in the high fluorine-aluminum group, being （ 82.82 ± 11.00） μmol/L,（8.16 ± 0.45 ）, （ 1.46 ± 0.09 ） mmol/L, （ 15.69 ± 2.38 ） μmol/L, respectively, all decreased significantly （P 〈 0.05 ）. Compared with the high aluminum grou