中文摘要：

目的采用T1加权动态对比增强磁共振成像（T1W-DCE-MRI）对腰椎骨髓进行定量灌注分析,观察椎体骨髓灌注与邻近椎间盘退变的关系。方法将72例接受DCE-MRI的患者分为3组,组1：纳入同时包含有1个位于退变椎间盘间的椎体和一个位于正常椎间盘间的椎体的受检者;组2：纳入2个均位于正常椎间盘间的椎体的受检者;组3：纳入2个均位于退变椎间盘间的椎体的受检者。选用3.0T超导MR LAVA-XV序列行腰椎动态采集,采用GE Cine Tool软件拟合时间-信号强度（TIC）曲线,计算各组定量参数Ktrans、Kep、Ve,并行标准化处理,获得各组各参数的标准化比率。结果组1、组2、组3三组间初始Ktrans、Kep、Ve的差异均无统计学意义（P均〉0.05）。标准化处理后,三组间标准化Ktrans、标准化Kep的差异有统计学意义（P均〈0.001）;组内两两比较,组1标准化Ktrans、标准化Kep均小于组2、组3（P均〈0.05）、而组2与组3差异无统计学意义（P均〉0.05）;三组间标准化Ve的差异无统计学意义（F=3.028,P=0.16）。结论腰椎椎体骨髓灌注减低和相邻椎间盘退变密切相关,T1W-DCE-MRI椎体骨髓定量灌注参数变化可为椎间盘退变的血流动力学病理机制提供一种新的影像学证据。

英文摘要：

Objective To quantitatively analyze marrow perfusion of lumbar vertebral body using T1-weighted dynamic contrast-enhanced MRI（T1W-DCE-MRI）and to explore the relation between marrow blood perfusion and intervertebral disk degeneration.Methods Seventy-two patients who underwent dynamic contrast-enhanced MRI of the lumbar spine were divided into three groups.In group 1,one of the vertebral bodies located between two adjacent normal disks and the other located between two adjacent degenerated disks.In group 2,each of the two vertebral bodies located between two normal disks.In group 3,each of the two vertebral bodies located between two degenerated disks.The quantitative perfusion parameters（Ktrans,Kep,Ve）of each vertebral body was calculated from time signal intensity curve（TIC）fitting of LAVA-XV（3D-GRE-T1WI）dynamic imaging data with Cine Tool software.In addition,the normalized ratio of parameters was calculated.Results There were no statistically significant differences in original values of Ktrans,Kep,Veamong groups 1,2and 3（all P〉0.05）.After normalization,the quantitative perfusion parameters（Ktrans,Kep）in group 1was significantly lower than that in group 2and group 3（both P〈0.05）,while there was no significant difference between group 2and group 3（P〉0.05）,normalized Veshowed no statistically significant difference among the three groups.ConclusionThe reduction of marrow perfusion is correlated well with adjacent disk degeneration in lumbar vertebra.T1W-DCE-MRI might be provide a new radiographic evidence to study the etiology and pathogenesis of lumbar disc degenerative disease.