以查尔酮4和取代的α-氯代吡唑甲醛肟3为原料,通过1,3-偶极环加成反应得到了16种新型的含吡唑基异噁唑衍生物,方法简单可行.化合物4,5-二氢-3-(1-苯基-3-甲基-5-取代-4-基)-5-芳基-4-芳酰基异噁唑啉(5)的结构经过IR,1HNMR,MS及元素分析确证.并利用单晶X射线衍射法测定了5g晶体结构.
Sixteen new isoxazole derivatives containing pyrazole moiety were synthesized simply and feasibly by chalcone 4 and substituted pyrazolohydroximinoyl chlorides 3 as stating materials through 1,3-dipolar cycloaddition reaction. The structures of 4,5-dihydro-3-(1-pnenyl-3-methyl-5-substituted-4-yl)-5-aryl-4-aroylisoxazolines (5) were confirmed by IR,1H NMR,MS techniques and elemental analysis. Compound 5g was subjected to X-ray single crystal diffraction analysis to determine crystallographic structure.