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中文摘要：
合成厂Co@SiO2核壳式纳米粒子，并采用透射电镜（TEM）、X射线衍射（XRD）、扫描电镜（SEM）和振动样品磁强计（VSM）对其形状、尺寸、荧光及磁特性进行了表征，探讨了其在细胞分离和细胞芯片上的应用和原理．
英文摘要：
In this paper, Co@ SiO2 nanoparticles with the apparent core-shell magnetic nanostructure were synthesized by reducing and hydrolysis in aqueous solutions. The TEM, VSM, SEM, and the confocal fluorescence microscope were utilized to characterize the morphology, size, magnetism of the Co @ SiO2 nanoparticles, and the core-shell materials were applied to the cell separation, immunophenotyping of leukemias and lymphomas diagnostics chip, in which strenuous procedures were omitted by the use of the magnetic core-shell nanoparticles, and separation. These core-shell nanoparticles were proved to have obvious cores and shell, and the cores have strong magnetism, and the shell protected these nanosized metal particles from coagulation due to anistropic dipolar attraction and oxidation very well. However this method could not limited the original cores below the size of 10 nm, which is the critical size of superparamagnetisizm, as a result coagulation due to remanent magnetism limited this core-shell particles from further applications in bioseparation.
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