中文摘要：

Gli1蛋白和血小板衍生生长因子受体α（PDGFRα）的表达在大肠癌的发生发展过程中的作用还不清楚.通过免疫组化法检测60例大肠癌及30例正常组织中Gli1和PDGFRα的表达,并与临床病理因素进行相关性分析,研究两者在大肠癌中的作用.研究发现,Gli1和PDGFRα蛋白在大肠癌组织中的阳性率分别为73.7%和78.3%,明显高于正常组织的表达（P〈0.05）.Gli1和PDGFRα蛋白表达与患者年龄、肿瘤大小、组织学类型等均无关（P〉0.05）,但是Gli1蛋白和PDGFRα表达与淋巴结转移状况和Duke分期相关（P〈0.05）.Spear-man相关分析显示,Gli1与PDGFRα蛋白表达正相关（r=0.298,P〈0.05）.结果表明Gli1和PDGFRα在大肠癌发生、发展中呈协同和相互调节作用,Gli1和PDGFRα的表达参与大肠癌的侵袭和转移过程.联合检测可作为判断大肠癌预后,筛选高危转移患者的有效指标,同时也可用于指导大肠癌的靶向药物治疗.

英文摘要：

The expression of Gli1 and platelet derived growth factor receptor-alpha（PDGFRα）in the occur-rence and development of colorectal cancer is not clear.The expression of Gli1 and PDGFRα in 60 cases of colorectal cancer and 30 cases of normal colorectal tissue was assessed by immunohistochemistry,and its correlation with clinicopathological factors was statistically analyzed to investigate the effect of Gli1 and PDGFRα proteins on colorectal cancer.The positive rates of Gli1 and PDGFRα protein in colorectal cancer were 73.3% and 78.3% respectively,significantly higher in colorectal cancer than those in normal tissue（P0.05）.The expression of Gli1 and PDGFRα in colorectal cancer had no correlation to patients＇ age,tu-mor size,pathologic type（P0.05）,but had a good correlation with lymph node metastasis and Duke stage（P0.05）.Gli1 expression was positively correlated to PDGFRα expression（r=0.298,P0.05）.Gli1 and PDGFRα have synergetic and mutual regulation in the occurrence and development of colorectal cancer,and both participate in the development,invasion and metastasis process of colorectal cancer.Their joint detection can be looked upon as an important symbol for judging the prognosis of colorectal cancer,screen-ing the high-risk metastasis patients and guiding the target-therapy of colorectal cancer.