欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
生物体中微环境的改变与许多生理、病理过程密切相关。因此,获取生物体系中局部环境信息、监控微环境的改变,对相关疾病的早期诊断与病理研究具有重要的意义。荧光探针由于具有分析灵敏度高、样品时空分辨能力强等特点,已在该方面获得了广泛的应用。根据不同的环境敏感性,本文简要评述对极性、pH、黏度及温度因素敏感的荧光探针及其在生命科学领域应用的研究进展,包括我们实验室近年来在该方面所取得的一些研究结果。
英文摘要：
The alterations of locally environmental parameters（e.g.polarity,pH,viscosity and temperature） in biosystems correlate closely with some physiological function disorders.Therefore,the precise measurements of these parameters are of great importance for the explanation of complicated biological processes and diagnoses of some related diseases.Because of their high spatial and temporal resolution capability,many environment-sensitive fluorescent probes have been developed and used in life sciences.In this paper,a brief review is given on the progress and applications of various biologically environment-sensitive fluorescent probes,including some of the related results from our laboratory.
同期刊论文项目
同项目期刊论文
Small Molecule-Capped Gold Nanoparticles as Potent Antibacterial Agents That Target Gram-Negative Ba
Noncovalent Attachment of NAD(+) Cofactor onto Carbon Nanotubes for Preparation of Integrated Dehydr
Highly Sensitive, Colorimetric Detection of Mercury(II) in Aqueous Media by Quaternary Ammonium Grou
A simple PDMS-based microfluidic channel design that removes bubbles for long-term on-chip culture o
In Situ Formation of Three-Dimensional Uniform Pt/Carbon Nanotube Nanocompositesfrom Ionic Liquid/Ca
Loop-Mediated Isothermal Amplification Integrated on Microfluidic Chips for Point-of-Care Quantitati
Sensitive impedimetric DNA biosensor with poly(amidoamine) dendrimer covalently attached onto carbon
A facile method for preparation of graphene film electrodes with tailor-made dimensions with Vaselin
Effective Electrochemical Method for Investigation of Hemoglobin Unfolding Based on the Redox Proper
A facile approach to construction of a stable water-miscible ionic liquid/electrolyte interface with
Dynamic regional changes of extracellular ascorbic acid during global cerebral ischemia: Studied wit
Electrospinning of Poly(dimethylsiloxane)/Poly(methyl methacrylate) Nanofibrous Membrane: Fabricatio
Using Azobenzene-Embedded Self-Assembled Monolayers To Photochemically Control Cell Adhesion Reversi
Label-free and sequence-specific DNA detection down to a picomolar level with carbon nanotubes as su
Incorporation of electrospun nanofibrous PVDF membranes into a microfluidic chip assembled by PDMS a
Assay of vitamin B in urine by capillary electrochromatography with methacrylate-based monolithic co
Parallel comparative studies on the toxic effects of unmodified CdTe quantum dots, gold nanoparticle
A spectroscopic off-on probe for simple and sensitive detection of carboxylesterase activity and its
A novel chiral ligand exchange capillary electrophoresis system with amino acid ionic liquid as liga
Imaging Different Interactions of Mercury and Silver with Live Cells by a Designed Fluorescence Prob
A simple and sensitive method for visual detection of phosgene based on the aggregation of gold nano
Magnetically separable Fe3O4-Ag3PO4 sub-micrometre composite: facile synthesis, high visible light-d
7-((5-Nitrothiophen-2-yl)methoxy)-3H-phenoxazin-3-one as a spectroscopic off-on probe for highly sen
Charge-transfer interaction between melamine and quinones: Towards voltammetric determination of mel
In situ formation of three-dimensional and uniform Pt/Carbon nanotube nanocomposites from ionic liqu
Microchip CE-LIF method for the hydrolysis of L-glutamine by using L-asparaginase enzyme reactor bas
Cysteine-modulated colorimetric sensing of extracellular Mg2+ in rat brain based on the strong chela
Real-time colorimetric assay of inorganic pyrophosphatase activity based on reversibly competitive c
ZeoliticImidazolate framework-based electrochemical biosensor for in vivo electrochemical measuremen
Microfluidic chip-based online electrochemical detecting system for continuous and simultaneous moni
Photodecomposition of Ferrocenedicarboxylic Acid in Methanol to Form an Electroactive Infinite Coord
Folic acid-functionalized fluorescent gold nanoclusters with polymers as linkers for cancer cell ima
Hybridization of Bioelectrochemically Functional Infinite Coordination Polymer Nanoparticles with Ca
Immobilization of trypsin via reactive polymer grafting from magnetic nanoparticles for microwave-as
Competitive Coordination of Cu2+ between Cysteine and Pyrophosphate Ion: Toward Sensitive and Select
Bioelectrochemically Active Infinite Coordination Polymer Nanoparticles: One-Pot Synthesis and Biose
Sensitive and selective voltammetric measurement of Hg2+ by rational covalent functionalization of g
Study on the decrease of renal D-amino acid oxidase activity in the rat after renal ischemia by chir
A graphene oxide-peptide fluorescence sensor tailor-made for simple and sensitive detection of matri
Rhodamine B Piperazinoacetohydrazine: A Water-Soluble Spectroscopic Reagent for Pyruvic Acid Labelin
Use of a rhodamine-based bifunctional probe in N-terminal specific labeling of Thermomyces lanuginos
A highly specific ferrocene-based fluorescent probe for hypochlorous acid and its application to cel
Determination of sodium benzoate by chiral ligand exchange CE based on its inhibitory activity in D-
Online Electrochemical Measurements of Ca2+ and Mg2+ in Rat Brain Based on Divalent Cation Enhanceme
A non-oxidative electrochemical approach to online measurements of dopamine release through laccase-
Potential-controllable green synthesis and deposition of metal nanoparticles with electrochemical me
Spectroscopic Response of Ferrocene Derivatives Bearing a BODIPY Moiety to Water: A New Dissociation
An unprecedented strategy for selective and sensitive fluorescence detection of nitric oxide based o
A new resorufin-based spectroscopic probe for simple and sensitive detection of benzoyl peroxide via
Reactive polymer as a versatile toolbox for construction of multifunctional superparamagnetic nanoco
Amphiphilic block copolymer modified magnetic nanoparticles for microwave-assisted extraction of pol
A versatile method for the preparation of polyacrylamide derivative functionalized thermo-responsive
Preparation of poly(N-isopropylacrylamide)-grafted well-controlled 3D skeletal monolith based on E-5
A colorimetric sensor for determination of cysteine by carboxymethyl cellulose-functionalized gold n
A chiral ligand exchange CE essay with zinc(II)-L-valine complex for determining enzyme kinetic cons
Distinguishing Folate-Receptor-Positive Cells from Folate-Receptor-Negative Cells Using a Fluorescen
Fluorescence sensing of adenosine deaminase based on adenosine induced self-assembly of aptamer stru
Nitroreductase Detection and Hypoxic Tumor Cell Imaging by a Designed Sensitive and Selective Fluore
Alkaline Post-Treatment of Cd(II)-Glutathione Coordination Polymers: Toward Green Synthesis of Water
Facile one-pot synthesis of L-proline-stabilized fluorescent gold nanoclusters and its application a
Monolith and coating enzymatic microreactors of L-asparaginase: kinetics study by MCE-LIF for potent
In vivo electrochemical monitoring of the change of cochlear perilymph ascorbate during salicylate-i
Strong Interaction between Imidazolium-Based Polycationic Polymer and Ferricyanide: Toward Redox Pot
Analysis of local polarity change around Cys34 in bovine serum albumin during N -> B transition by a
New Approach for Local Structure Analysis of the Tyrosine Domain in Proteins by Using a Site-Specifi
Analysis of local structure of Arg10 domain in apo-alpha-lactalbumin with a polarity-sensitive argin
位置：