中文摘要：

目的 观察有氧运动联合药物治疗方案对心衰大鼠脑钠肽前体（NT-proBNP）及肿瘤坏死因子-α（TNF-α）的影响机制.方法 将50只SD大鼠随机分为正常对照组（10只）与模型组（40只）,模型组采用阿霉素腹腔注射7周造模,每周0.75 mL/kg,注射2次,共21 mg/kg.造模成功后,随机分为心衰模型组、呋塞米治疗组、有氧运动治疗组、运动呋塞米合治组.分别用生理盐水、呋塞米、有氧运动、有氧运动联合呋塞米干预4周,再从腹主动脉采血,离心后提取上清液,用ELISA法检测NT-proBNP与TNF-α.结果 与正常对照组比较,其他4组NT-proBNP与TNF-α明显增高,差异有统计学意义（P＜0.01）;与心衰模型组比较,NT-proBNP与TNF-α在有氧运动治疗组、呋塞米治疗组、运动呋塞米合治组呈逐渐下降趋势,差异有统计学意义（P＜0.01）;与有氧运动、呋塞米治疗组比较,运动呋塞米合治组最低（P＜0.01）.结论 有氧运动联合呋塞米治疗方案可以明显降低NT-proBNP与TNF-α指标,值得进一步研究.

英文摘要：

Objective Observe the effect aerobic exercise training combined with drug on N-terminal pro-brain natriuretic peptide （NT-proBNP） and tumor necrosis factor-a （TNF-a） of heart failure rats and its mechanism. Methods 50 SD rats were randomly divided into normal control group （10） and model group （40）, the model groups were injected intraperitoneally for seven weeks of doxorubicin, 0.75 mL/kg×2 per week, and a total of 21 mg/kg. Then it were randomly divided into heart failure model group, furosemide therapy group, aerobic exercisetherapy group, and aerobic exercise training combined with furosemide treatment group. The groups were intervened for four weeks by saline, furosemide, aerobic exercise and erobic exercise training combined with furosemide, respectively. The blood was collected from abdominal aorta and the supernatant was extracted after centrifugatioα NT-proBNP and TNF-α were detected by ELISA. Results Compared with the normal control group, NT-proBNP and TNF-α were significantly higher than the other four groups, the difference was significant （P〈0.01）. Compared with the model groups of heart failure, NT-proBNP and TNF-α were significantly lower in the aerobic exercise group, furosemide therapy group and aerobic exercise training combined with furosemide treatment group, showed a gradual downward trend, the difference was significant （P〈0.01）; compared with the aerobic exercise and furosemide group, aerobic exercise training combined with furosemide treatment group was the lowest （P〈0.01）. Conclusion Aerobic exercise training combined with drug treatment can significantly reduce the level of NT-proBNP and TNF-α, so it is worthy of further study.