中药在人们的日常生活中发挥着重要的作用,但其化学成分种类繁多、结构多样且复杂,令分析鉴定工作存在有较大的难度,由于许多中药的药效物质基础不明,从而无法保证临床安全、有效、合理地用药。在中药现代化进程中,如何对中药化学成分进行全面的分析,是药效物质基础研究的关键。在诸多分析技术中,质谱发挥着举足轻重的作用,尤其是高分辨质谱。文章综述了中药化学成分分析和鉴定中常用的质谱技术和策略,讨论了高分辨质谱的特点和优势,以期为合理应用高分辨质谱进行中药化学成分研究提供参考。
Traditional Chinese Medicine is playing an increasingly important role in daily life,but the analysis of chemical composition is very difficult because its chemical constituents are various,diverse,low content and their structure is very complex.How to analyze and identify the constituents is the key factor of the development of the modernization of traditional Chinese medicine.Mass spectrometry,especially high resolution mass spectrometry,plays a decisive role in the current analysis techniques.This paper reviewed the mass spectrometry technique and strategy used in the analysis and identification of the traditional Chinese medicine,and focused on the characteristics and advantages of high resolution mass spectrometry in the analysis process.It will be helpful for more reasonable application of high resolution mass spectrometry to analyze the chemical components of traditional Chinese medicine faster and better.