位置:成果数据库 > 期刊 > 期刊详情页
Evolutionary characteristics of exons expressed at different abundance levels in mammals
  • ISSN号:1001-6538
  • 期刊名称:科学通报(英文版)
  • 时间:0
  • 页码:3546-3554
  • 语言:中文
  • 分类:Q95[生物学—动物学]
  • 作者机构:[1]Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center of Yunnan University, Kunming 650091, China, [2]Beijing Genomics Institute at Shenzhen, Shenzhen 518083, China, [3]CAS-Max Planck Junior Research Group and State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
  • 相关基金:Supported by the National Natural Science Foundation of China (Grant Nos. 30871342, J073652, 30660076 and 30740420553), Western Light Program and Yunnan Province Young Scientist Project (Grant No. 2008PY025), Undergraduate Science Novelty Training Project by Yunnan University Life Science Laboratory Center The authors would like to thank ZHAO RuoPing and ZHANG Yue for technical supports.
  • 相关项目:果蝇CG12765基因功能和分子机制的研究
中文摘要:

与比较基因组学途径,我们评估了富有地被表示的前 ons 的保存的进化特征,中等或在哺乳动物低层。用非编码的区域和假基因,作为控制,顺序身份, phastCons 和 Ka/Ks,分析被执行,当高丰富的前 ons 高度被保存,我们的结果显示出那,次要、低的前 ons 也在进化显示出保守特征。我们的调查结果建议有在有机体的 transcriptome 组成不同种类的一个大比例的更少的丰富的前 ons 在功能的限制下面并且可能在在有机体的进化充实生物复杂性起某些作用。

英文摘要:

With comparative genomics approaches, we evaluated the evolutionary characteristics of conservation of exons which are expressed abundantly, moderately or lowly in mammals. Using non-coding regions and pseudogenes as controls, sequence identity, phastCons and KalKs analyses were carried out and our results showed that as the exons of high abundance are highly conserved, the minor and low exons also showed conservative characteristics in evolution. Our findings suggested that the exons with less abundance which constitute a large proportion of distinct species in transcriptome of organisms are under functional constraint and might play certain roles in enriching biological complexity in the evolution of organisms.

同期刊论文项目
同项目期刊论文