中文摘要：

FGFR3是成纤维细胞生长因子受体（fibroblast growth factor receptors，FGFRs）家族成员之一，在骨骼发育中起重要作用。FGFR3的激活突变引起一系列骨骼发育缺陷性疾病，如软骨发育不全（aehondroplasia，ACH）、季肋发育不全（hypochondroplasia,HCH）和致死性骨发育不全（thanatophoric dysplasia，TD）。目前研究认为，FGFR3在骨骼发育中抑制软骨形成的作用是明确的，但其对骨形成的作用尚不明确，需要进一步研究。

英文摘要：

Fibroblast growth factor receptors 3（FGFR3） is one of the family of 4 membrane bound receptor tyrosine kinases （FGFR1-4） that mediate signals of at least 22 Fibroblast growth factors （FGF1-22）, which plays an important role in skeleton development and diseases. The chondrodysplasia ：syndromes including hypochondroplasia （HCH）, achondroplasia （ACH）, and thanatophoric dysplasia （TD） are caused by gain-of-function mutations in FG- FR3, and their major skeletal defects are found in long bone formed through cndochondral ossification. Studies show that FGFR3 can inhibit chondrogenesis , but people still don＇t know its effect on bone formation clearly.