中文摘要：

目的：探讨ACE基因1／13多态性与HiHiLo训练敏感性的关联性。方法：选取71名中国北方平原地区汉族男子进行4周高住高练低训（HiHiLo），方案为每日在低氧环境（O2浓度为14．5％-14．8％，大约相当于海拔3000m）中休息10h，每周进行3次75％VOzmax低氧训练（Q浓度为15．4％，大约相当于海拔2500m），其余时间在常氧下训练；测试其HiHiLo前后的V02max及训练期间的血象指标；PCR分析受试者的ACE基因I／D多态性。结果：训练前各组基础值经方差检验无显著性差异；训练后，VChmax、VO2max／W、RBC、FIB和HCT在整体及II、ID组都极显著性提高（P〈0．01），但GG组除HCT显著提高外（P〈0．05），其他各指标虽有上升，但都没有统计学意义（P〉0．05）。结论：HiHiL0能够提高有氧能力；携带ACE基因II和ID型的人有对低氧训练更敏感的趋势。

英文摘要：

Objective： To explore the association between Insertion/Deletion polymorphisrn of the angiotensin con- verting enzyme（ACE） gene and the effects of HiHiLo （living at high altitude-exercise at high altitude-training at low altitude） training. Method： Seventy-one healthy men of Han nationality in northern China underwent HiHiLo training for 4 weeks. Training programme was as follows： exposure in hypoxic environment （14.5 % -14.8 % 02, 10h/day）, three times hypoxic training per week （15.4%O2）, and training at sea level. VO2max and Haemogram were measured before and after the protocol, and the ACE gene I/D polymorphism was detected by PCR. Result： The findings indicated that the frequency of genotypes in the subjects was in Hardy-Weinberg equi- librium No significant differences were in the baseline VO2max, VO2max/W、 RBC、 HB and HCT among groups. VO2max、VO2max/W、Rt3C、HB and HCT all increased more significantly in total and II,ID after train- ing than those before the training（P 〈 0.01 ）, but no significant changes showed in GG（P 〉 0.05） except HCT. Conclusion： The present study suggested that HiHiLo could be helpful for developing aerobic ability. Moreover, men carrying II and ID probably were more sensitive to the hypoxic training than those carrying DD.